Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR3 | P32745 | 1/20 | 0.60 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.55 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 2/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGAV | P06756 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3560619 | 0.86 | IDO1 (0.58) | SSTR3METTL3METTL14IDO1MTNR1A | |
| SCHEMBL28852764 | 0.85 | MTNR1A (0.70) | SSTR3IDO1MTNR1AMTNR1BNPC1 | |
| SCHEMBL17149913 | 0.85 | NPC1 (0.57) | SSTR3NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL29411078 | 0.82 | GPR84 (0.64) | SSTR3MTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL13415981 | 0.81 | MTNR1A (0.73) | METTL3METTL14IDO1MTNR1AMTNR1B | |
| SCHEMBL11856052 | 0.79 | LOXL2 (0.56) | METTL3METTL14IDO1MTNR1AMTNR1B | |
| SCHEMBL13405930 | 0.78 | HPGD (0.65) | METTL3METTL14NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10962102 | 0.78 | IMPDH2 (0.48) | MTNR1AMTNR1BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1382509 | 0.78 | L3MBTL1 (0.55) | METTL3METTL14IDO1MTNR1AMTNR1B | |
| SCHEMBL1381256 | 0.78 | IDO1 (0.59) | SSTR3METTL3METTL14IDO1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225894-B1 | FAB I INHIBITORS | AFFINIUM PHARM INC (CA) | 2006-07-05 | — | — | EP | disclosed |
| EP-1225894-A4 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1225894-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001026652-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-19 | — | — | WO | disclosed |