SCHEMBL578643

SCHEMBL578643

O/N=C/Cc1c[nH]c2ccccc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 7/20 0.56
KMT2A Q03164 7/20 0.56
CYP3A4 P08684 4/20 0.56
MAPT P10636 4/20 0.56
AHR P35869 1/20 0.56
GPR84 Q9NQS5 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
HPGD P15428 3/20 0.53
HTT P42858 2/20 0.53
ALDH1A1 P00352 6/20 0.50
CYP2D6 P10635 4/20 0.50
KDM4E B2RXH2 3/20 0.50
HSD17B10 Q99714 3/20 0.50
CYP1A2 P05177 2/20 0.50
MPO P05164 1/20 0.50
CYP2A6 P11509 1/20 0.50
NFKB1 P19838 1/20 0.50
HTR1D P28221 1/20 0.50
HTR1B P28222 1/20 0.50
HTR2A P28223 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25029869 1.00 MEN1 (0.56) MEN1KMT2ACYP3A4MAPTAHR
SCHEMBL29501708 1.00 MEN1 (0.56) MEN1KMT2ACYP3A4MAPTAHR
SCHEMBL578644 1.00 MEN1 (0.56) MEN1KMT2ACYP3A4MAPTAHR
SCHEMBL13253481 0.81 MEN1 (0.55) MEN1KMT2ACYP3A4MAPTAHR
SCHEMBL5846319 0.80 MEN1 (0.62) MEN1KMT2ACYP3A4MAPTAHR
SCHEMBL31355130 0.80 MEN1 (0.53) MEN1KMT2ACYP3A4MAPTAHR
SCHEMBL10382799 0.80 MEN1 (0.67) MEN1KMT2ACYP3A4MAPTAHR
Indole-3-Carbinol SCHEMBL63995 0.77 MEN1 (0.69) MEN1KMT2ACYP3A4MAPTAHR
Indole-3-Carbinol SCHEMBL30082813 0.77 MEN1 (0.69) MEN1KMT2ACYP3A4MAPTAHR
SCHEMBL9670836 0.77 FAAH (0.54) MEN1KMT2AMAPTHPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 250 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020245629-A1 MIXTURES AND COMPOSITIONS OF FLUENSULFONE AND AUXIN, AND USES THEREOF ADAMA MAKHTESHIM LTD> (IL) 2020-12-10 WO claimed
US-20160331725-A1 USE OF COMPOUNDS THAT ARE ABLE TO INCREASE THE SERUM IGF-1 LEVEL FOR THE PREPARATION OF A THERAPEUTICAL COMPOSITION FOR TREATMENT OF VARIOUS DISEASE STATES ASSOCIATED WITH A REDUCED IGF-1 SERUM LEVEL IN HUMANS AND ANIMALS VEIJLEN N.V. 2016-11-17 US claimed
WO-2016044655-A2 FUSION PROTEINS, RECOMBINANT BACTERIA, AND METHODS FOR USING RECOMBINANT BACTERIA SPOGEN BIOTECH INC. (US) 2016-03-24 WO claimed
US-20160031948-A1 FUSION PROTEINS AND METHODS FOR STIMULATING PLANT GROWTH, PROTECTING PLANTS, AND IMMOBILIZING BACILLUS SPORES ON PLANTS GENISYS CREDIT UNION 2016-02-04 US claimed
EP-2970507-A1 FUSION PROTEINS AND METHODS FOR STIMULATING PLANT GROWTH, PROTECTING PLANTS, AND IMMOBILIZING BACILLUS SPORES ON PLANTS Spogen Biotech Inc. (US) 2016-01-20 EP claimed
WO-2014145964-A1 FUSION PROTEINS AND METHODS FOR STIMULATING PLANT GROWTH, PROTECTING PLANTS, AND IMMOBILIZING BACILLUS SPORES ON PLANTS SPOGEN BIOTECH INC. (US) 2014-09-18 WO claimed
US-20120135864-A1 POLLINATION IMPROVER TAMINCO, NAAMLOZE VENNOOTSCHAP (BE) 2012-05-31 US claimed
US-20120108431-A1 PLANT GROWTH REGULATOR ADDITIVE TAMINCO, NAAMLOZE VENNOOTSCHAP (BE) 2012-05-03 US claimed
US-20120101164-A1 ABSCISSION AND CROP STORAGE UNIT TAMINCO, NAAMLOZE VENNOOTSCHAP (BE) 2012-04-26 US claimed
US-20120088668-A1 THINNING AGENT TAMINCO, NAAMLOZE VENNOOTSCHAP (BE) 2012-04-12 US claimed
WO-2010116256-A2 THINNING AGENT TAMINCO, NAAMLOZE VENNOOTSCHAP (BE) 2010-10-14 WO claimed
WO-2010116259-A2 PLANT GROWTH REGULATOR ADDITIVE TAMINCO, NAAMLOZE VENNOOTSCHAP (BE) 2010-10-14 WO claimed
WO-2010116260-A2 POLLINATION IMPROVER TAMINCO, NAAMLOZE VENNOOTSCHAP (BE) 2010-10-14 WO claimed
WO-2010116263-A2 ABSCISSION AND CROP STORAGE AGENT TAMINCO, NAAMLOZE VENNOOTSCHAP (BE) 2010-10-14 WO claimed
US-20070130640-A1 Methods of modulating auxin production in plants THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA A ARIZONA CORPORATION, 2007-06-07 US claimed
EP-1670444-A2 USE OF INDOLEACETIC ACID DERIVATIVES WHICH INCREASE THE SERUM IGF-1 LEVEL FOR THE PREPARATION OF A THERAPEUTICAL COMPOSITION FOR TREATMENT OF VARIOUS DISEASES Veijlen N.V. (AN) 2006-06-21 EP claimed
WO-2005039546-A2 USE OF INDOLEACETIC ACID DERIVATIVES WHICH INCREASE THE SERUM IGF-1 LEVEL FOR THE PREPARATION OF A THERAPEUTICAL COMPOSITION FOR TREATMENT OF VARIOUS DISEASES VEIJLEN N.V. (AN) 2005-05-06 WO claimed
US-20030166202-A1 P450 Monooxygenases of the cyp79 family ROYAL VETERINARY AND AGRICULTURAL UNIVERSITY (DK) 2003-09-04 US claimed
EP-1246906-A2 P450 MONOOXYGENASES OF THE CYP79 FAMILY Syngenta Participations AG (CH) 2002-10-09 EP claimed
WO-2001051622-A2 P450 MONOOXYGENASES OF THE CYP79 FAMILY SYNGENTA PARTICIPATIONS AG (CH) 2001-07-19 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120101164-A1 ABSCISSION AND CROP STORAGE UNIT BROX, ACR, ABAT MEN1 4059/4885KMT2A 4125/4885CYP3A4 719/4885
US-20120088668-A1 THINNING AGENT NAT1, MAP2, AANAT MEN1 3321/4885KMT2A 3903/4885CYP3A4 804/4885
US-20120135864-A1 POLLINATION IMPROVER AADAT, TIPARP, GSR MEN1 3460/4885KMT2A 3315/4885CYP3A4 68/4885
US-20120108431-A1 PLANT GROWTH REGULATOR ADDITIVE MYB, ING2, AGXT MEN1 4545/4885KMT2A 710/4885CYP3A4 4192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.