Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 3/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.36 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5790783 | 0.89 | PIK3CA (0.45) | KDM1AHDAC1HDAC6KCNQ3KCNQ2 | |
| SCHEMBL4474830 | 0.85 | RAB9A (0.50) | NAMPTKDM1AHDAC1HDAC6CTNNB1 | |
| SCHEMBL5353997 | 0.80 | NAMPT (0.51) | CES2CES1VNN1NAMPTHDAC1 | |
| SCHEMBL14143222 | 0.79 | MAPT (0.44) | CES1CTNNB1WNT3AGABRPGABRD | |
| SCHEMBL5789404 | 0.79 | ERCC5 (0.46) | VNN1KCNQ3KCNQ2KCNQ5PIK3CA | |
| SCHEMBL6643878 | 0.77 | LMNA (0.43) | RAB9A | |
| SCHEMBL22589329 | 0.74 | CES2 (0.40) | CES2CES1KDM1AHDAC1HDAC6 | |
| SCHEMBL22075469 | 0.74 | VNN1 (0.38) | CES2CES1VNN1KCNQ3KCNQ2 | |
| SCHEMBL3618613 | 0.74 | LOXL2 (0.45) | HDAC1HDAC6KCNQ2GABRPGABRD | |
| SCHEMBL1515798 | 0.73 | MAPT (0.61) | CES2CES1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543003-B1 | IMIDAZO¬1,2-A|PYRIDINES | SMITHKLINE BEECHAM CORP (US) | 2006-05-17 | — | — | EP | disclosed |
| US-20050245520-A1 | 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors | DODIC NERINA | 2005-11-03 | — | — | US | disclosed |
| US-20050234029-A1 | Compounds | DODIC NERINA | 2005-10-20 | — | — | US | disclosed |
| EP-1543003-A2 | IMIDAZO[1,2-A]PYRIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004013138-A2 | IMIDAZO`1,2-A!PYRIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245520-A1 | 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors | SMAD2, SMAD3, ALK | CES2 4667/4885CES1 3686/4885VNN1 4098/4885 |
| US-20050234029-A1 | Compounds | SMAD3, SMAD2, ACVR1 | CES2 4581/4885CES1 4089/4885VNN1 4473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.