Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29517255 | 0.84 | LMNA (0.49) | ALDH1A1LMNAGAAL3MBTL1CYP2C9 | |
| SCHEMBL607557 | 0.81 | ALDH1A1 (0.65) | ALDH1A1LMNAGAAL3MBTL1CYP2C9 | |
| SCHEMBL12822014 | 0.79 | ALDH1A1 (0.49) | ALDH1A1LMNAGAAL3MBTL1CYP2C9 | |
| SCHEMBL27214503 | 0.78 | ALDH1A1 (0.52) | ALDH1A1GAAKDM4EMAPTHPGD | |
| SCHEMBL3684197 | 0.75 | ALDH1A1 (0.45) | ALDH1A1LMNAGAAL3MBTL1NPC1 | |
| SCHEMBL5785069 | 0.75 | ALDH1A1 (0.49) | ALDH1A1LMNAGAAL3MBTL1CYP2C9 | |
| SCHEMBL5784881 | 0.74 | PARP1 (0.42) | ALDH1A1LMNAGAAL3MBTL1NPC1 | |
| SCHEMBL5789102 | 0.73 | POLB (0.44) | ALDH1A1LMNAGAAL3MBTL1CYP2C9 | |
| SCHEMBL4096686 | 0.73 | MAPT (0.44) | ALDH1A1GAAL3MBTL1NPC1KDM4E | |
| SCHEMBL29528396 | 0.72 | CES2 (0.68) | ALDH1A1GAANPC1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646610-A1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SmithKline Beecham Corporation (US) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005005386-A1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-20 | — | — | WO | disclosed |