SCHEMBL5790641

SCHEMBL5790641

NC(=O)N1CCCC1(c1ccccc1)C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 2/20 0.39
NPSR1 Q6W5P4 2/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
AKR1C1 Q04828 1/20 0.37
ALDH1A1 P00352 4/20 0.36
PKM P14618 1/20 0.36
NR1H2 P55055 1/20 0.36
NR1H3 Q13133 1/20 0.36
TSHR P16473 3/20 0.35
MLYCD O95822 1/20 0.35
OPRM1 P35372 3/20 0.35
KDM4E B2RXH2 1/20 0.34
MAPT P10636 1/20 0.34
GRIN1 Q05586 2/20 0.34
GRIN2A Q12879 2/20 0.34
GRIN2D O15399 1/20 0.34
GRIN3B O60391 1/20 0.34
CHRM2 P08172 1/20 0.34
CHRM1 P11229 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5822059 0.96 MEN1 (0.42) HSD11B1NPSR1MEN1KMT2AAKR1C1
SCHEMBL5792213 0.91 HSD11B1 (0.37) HSD11B1MEN1KMT2AAKR1C1MLYCD
SCHEMBL5790959 0.79 SIGMAR1 (0.35) ALDH1A1TSHRMLYCDOPRM1KDM4E
SCHEMBL30493836 0.79 ALDH1A1 (0.37) NPSR1ALDH1A1TSHRKCNH2SMN1; SMN2
SCHEMBL5734399 0.74 HSD11B1 (0.41) HSD11B1NPSR1MEN1KMT2AAKR1C1
SCHEMBL23064670 0.72 NR1H2 (0.41) HSD11B1ALDH1A1NR1H2NR1H3TSHR
SCHEMBL11661570 0.72 MEN1 (0.47) HSD11B1NPSR1MEN1KMT2AAKR1C1
SCHEMBL24774463 0.71 OPRM1 (0.44) HSD11B1ALDH1A1NR1H2NR1H3OPRM1
SCHEMBL3433975 0.71 MEN1 (0.46) HSD11B1NPSR1MEN1KMT2AAKR1C1
SCHEMBL28415898 0.70 HPGD (0.36) HSD11B1NPSR1MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1483241-A4 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2006-12-13 EP claimed
EP-1483241-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Bristol-Myers Squibb Company (US) 2004-12-08 EP claimed
WO-2003075853-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2003-09-18 WO claimed
EP-1483241-A4 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2006-12-13 EP disclosed
EP-1483241-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Bristol-Myers Squibb Company (US) 2004-12-08 EP disclosed
WO-2003075853-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2003-09-18 WO disclosed