Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5260586 | 0.79 | NPC1 (0.47) | NPC1SMN1; SMN2LMNANPSR1HTR2A | |
| SCHEMBL14399666 | 0.77 | HTR2A (0.53) | NPC1LMNANPSR1HTR2AHTR1A | |
| SCHEMBL4982358 | 0.73 | MEN1 (0.54) | NPC1LMNANPSR1HTR2AHTR1A | |
| SCHEMBL6608957 | 0.73 | NPC1 (0.42) | NPC1SMN1; SMN2LMNANPSR1HTR2A | |
| SCHEMBL14921847 | 0.71 | OPRM1 (0.55) | NPC1SMN1; SMN2LMNANPSR1HTR2A | |
| SCHEMBL6608825 | 0.71 | NPC1 (0.41) | NPC1SMN1; SMN2LMNANPSR1HTR2A | |
| SCHEMBL31518326 | 0.71 | LMNA (0.64) | NPC1SMN1; SMN2LMNAHTR2AHTR1A | |
| SCHEMBL20970873 | 0.71 | HTR6 (0.75) | NPC1SMN1; SMN2HTR2AHTR1ASLC6A4 | |
| SCHEMBL29633016 | 0.71 | HTR6 (0.75) | NPC1SMN1; SMN2HTR2AHTR1ASLC6A4 | |
| SCHEMBL10617441 | 0.71 | MEN1 (0.58) | NPC1LMNANPSR1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651637-A1 | 3-AMINO CHROMAN AND 2-AMINO TETRALIN DERIVATIVES | Wyeth (US) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005012291-A1 | 3-AMINO CHOMAN AND 2-AMINO TETRALIN DERIVATIVES | WYETH (US) | 2005-02-10 | — | — | WO | disclosed |