Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14399666 | 0.78 | HTR2A (0.53) | NPC1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6608825 | 0.76 | NPC1 (0.41) | NPC1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL5260586 | 0.73 | NPC1 (0.47) | NPC1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL5792372 | 0.73 | NPC1 (0.46) | NPC1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL4982358 | 0.71 | MEN1 (0.54) | NPC1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL10993059 | 0.70 | HTR1A (0.46) | NPC1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL30995725 | 0.66 | PKM (0.62) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2187283 | 0.66 | PKM (0.62) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL10980705 | 0.65 | ALDH1A1 (0.53) | NPC1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL27474102 | 0.64 | LMNA (0.58) | NPC1SMN1; SMN2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379239-A2 | N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002078693-A2 | N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2002-10-10 | — | — | WO | disclosed |