Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.62 |
| ▸ | FAAH | O00519 | 3/20 | 0.61 |
| ▸ | CES1 | P23141 | 3/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253249 | 1.00 | MAPT (0.71) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL3250759 | 1.00 | MAPT (0.71) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL7768077 | 1.00 | MAPT (0.71) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL7883758 | 1.00 | MAPT (0.71) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL9664005 | 1.00 | MAPT (0.71) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL9664667 | 1.00 | MAPT (0.71) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL384438 | 0.98 | MAPT (0.68) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL8772423 | 0.94 | MAPT (0.82) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL61491 | 0.92 | HDAC1 (0.69) | MAPTRXFP1HDAC1HDAC2ALOX5 | |
| SCHEMBL27538484 | 0.90 | HDAC1 (0.67) | MAPTRXFP1HDAC1HDAC2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10174015-B2 | Substituted heterocyclic derivative, preparation method and use thereof | XIAMEN UNIVERSITY (CN) | 2019-01-08 | — | — | US | disclosed |
| US-20170334896-A1 | Substituted Heterocyclic Derivative, Preparation Method And Use Thereof | XIAMEN UNIVERSITY (CN) | 2017-11-23 | — | — | US | disclosed |
| WO-2006029818-A2 | COSMETIC COMPOSITIONS CONTAINING AN HYDROXAMIC ACID COMPOUND OPTIONALLY IN COMBINATION WITH A RETINOID | DSM IP ASSETS B.V. (NL) | 2006-03-23 | — | — | WO | disclosed |
| US-6147084-A | Brain cell protective agent | TORAY INDUSTRIES, INC. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5972953-A | MORPHINAN DERIVATIVE; USEFAL AS PREVENTIVE AND THERAPUETIC AGENTS OF ISCHEMIC BRAIN DISORDERS, BRAIN NERVE CELL DISORDERS AND DEMENTIA | TORAY INDUSTRIES, LTD. (JP) | 1999-10-26 | — | — | US | disclosed |
| EP-0661283-B1 | BRAIN CELL PROTECTIVE | TORAY INDUSTRIES (JP) | 1998-10-21 | — | — | EP | disclosed |
| EP-0661283-A1 | BRAIN CELL PROTECTIVE | TORAY INDUSTRIES, INC. (JP) | 1995-07-05 | — | — | EP | disclosed |
| US-5405989-A | Controlling house dust mites | SUMITOMO CHEMICAL CO., LTD. (JP) | 1995-04-11 | — | — | US | disclosed |
| EP-0597660-A2 | Propargyl ester compounds, acaricides containing the same as an active ingredient and an acaricidal method | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1994-05-18 | — | — | EP | disclosed |
| EP-0273451-B1 | LIPOXYGENASE INHIBITORY COMPOUNDS | Bristol-Myers Squibb Company (US) | 1992-04-01 | — | — | EP | disclosed |
| US-4861798-A | Lipoxygenase inhibitory compounds | BRISTOL-MYERS COMPANY (US) | 1989-08-29 | — | — | US | disclosed |
| EP-0273451-A2 | Lipoxygenase inhibitory compounds | Bristol-Myers Squibb Company (US) | 1988-07-06 | — | — | EP | disclosed |
| US-3992396-A | TRANQUILIZERS, HYPNOTICS | SANDOZ, INC. (US) | 1976-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334896-A1 | Substituted Heterocyclic Derivative, Preparation Method And Use Thereof | FAAH, NAAA, FAAH2 | MAPT 2676/4885RXFP1 2509/4885HDAC1 317/4885 |
| US-10174015-B2 | Substituted heterocyclic derivative, preparation method and use thereof | DHPS, CYP3A5, CYP3A4 | MAPT 3746/4885RXFP1 4818/4885HDAC1 646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.