Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 6/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5793049 | 1.00 | OSBP (0.55) | OSBPPTGS1PTGS2MAOAMAOB | |
| SCHEMBL5793866 | 0.81 | OSBP (0.55) | OSBPPTGS1PTGS2MAOAMAOB | |
| SCHEMBL5793862 | 0.81 | OSBP (0.55) | OSBPPTGS1PTGS2MAOAMAOB | |
| SCHEMBL3676767 | 0.78 | PTGS2 (0.66) | OSBPPTGS1PTGS2MAOAMAOB | |
| SCHEMBL3676768 | 0.78 | PTGS2 (0.66) | OSBPPTGS1PTGS2MAOAMAOB | |
| SCHEMBL3671081 | 0.77 | PTPN1 (0.58) | OSBPPTGS1PTGS2MAOAMAOB | |
| SCHEMBL3671080 | 0.77 | PTPN1 (0.58) | OSBPPTGS1PTGS2MAOAMAOB | |
| SCHEMBL8467358 | 0.73 | AKR1C3 (0.86) | OSBPPTGS1PTGS2MAOAMAOB | |
| SCHEMBL8467360 | 0.73 | AKR1C3 (0.86) | OSBPPTGS1PTGS2MAOAMAOB | |
| SCHEMBL4267621 | 0.73 | OSBP (0.55) | OSBPPTGS1PTGS2AKR1B10AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060106014-A1 | Methods for treating diabetes | ELI LILLY AND COMPANY | 2006-05-18 | — | — | US | claimed |
| WO-2006044556-A2 | DUAL INHIBITORS OF LIPOXYGENASE FOR TREATING DIABETES | GALILEO PHARMACEUTICALS, INC. (US) | 2006-04-27 | — | — | WO | claimed |
| US-20060106014-A1 | Methods for treating diabetes | ELI LILLY AND COMPANY | 2006-05-18 | — | — | US | disclosed |
| WO-2006044556-A2 | DUAL INHIBITORS OF LIPOXYGENASE FOR TREATING DIABETES | GALILEO PHARMACEUTICALS, INC. (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106014-A1 | Methods for treating diabetes | ALOX5, ALOX15, ALOX15B | OSBP 605/4885PTGS1 89/4885PTGS2 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.