Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | BMP1 | P13497 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270695 | 0.88 | LMNA (0.43) | LMNARECQLALDH1A1KMT2AHDAC1 | |
| SCHEMBL8269391 | 0.88 | LMNA (0.46) | LMNARECQLALDH1A1KMT2AHDAC1 | |
| Trifluoroacetic Acid SCHEMBL5791293 | 0.85 | BMP1 (0.41) | LMNARECQLALDH1A1KMT2AHDAC1 | |
| SCHEMBL5794707 | 0.81 | LMNA (0.43) | LMNARECQLCTSKALDH1A1KMT2A | |
| SCHEMBL5791966 | 0.79 | CTSK (0.45) | CTSKALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL8268844 | 0.76 | CTSK (0.45) | LMNARECQLCTSKALDH1A1KMT2A | |
| SCHEMBL8270702 | 0.76 | NPC1 (0.46) | LMNACTSKALDH1A1KMT2ANPC1 | |
| SCHEMBL8271448 | 0.75 | CTSK (0.46) | CTSKKMT2AHDAC1NPC1RAB9A | |
| SCHEMBL8245768 | 0.74 | CTSL (0.53) | LMNARECQLCTSKALDH1A1KMT2A | |
| SCHEMBL5791503 | 0.74 | CTSK (0.47) | CTSKALDH1A1HDAC1HDAC2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |