Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 2/20 | 0.46 |
| ▸ | MC3R | P41968 | 2/20 | 0.46 |
| ▸ | MC1R | Q01726 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.43 |
| ▸ | DAGLA | Q9Y4D2 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6429540 | 0.89 | HSD11B1 (0.58) | HSD11B1SCD5DPP4GABRA1GABRG2 | |
| SCHEMBL18862950 | 0.86 | HSD11B1 (0.48) | HSD11B1MC4RMC3RMC1RABCB1 | |
| SCHEMBL18862951 | 0.86 | HSD11B1 (0.48) | HSD11B1MC4RMC3RMC1RABCB1 | |
| SCHEMBL11760424 | 0.83 | HSD11B1 (0.46) | TACR1HSD11B1MC4RMC3RMC1R | |
| SCHEMBL27946634 | 0.82 | ABCB1 (0.62) | TACR1ABCB1 | |
| SCHEMBL2753534 | 0.80 | CA1 (0.63) | ABCB1DPP4 | |
| SCHEMBL4584365 | 0.80 | CA1 (0.63) | DPP4 | |
| SCHEMBL16197157 | 0.80 | PSEN1 (0.56) | TACR1HSD11B1MC4RMC3RMC1R | |
| SCHEMBL2753820 | 0.79 | CA1 (0.64) | GAAABCB1DPP4 | |
| SCHEMBL23459127 | 0.77 | SCD5 (0.57) | HSD11B1MC4RMC3RMC1RSCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620395-A1 | AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS | VERNALIS RESEARCH LIMITED (GB) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004096763-A1 | AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS | VERNALIS RESEARCH LIMITED (GB) | 2004-11-11 | — | — | WO | disclosed |