Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11096875 | 0.84 | AKR1B1 (0.38) | LMNAKMT2ARXFP1 | |
| SCHEMBL5801752 | 0.72 | MAPT (0.36) | MEN1KMT2AMAPT | |
| SCHEMBL6522978 | 0.70 | KEAP1 (0.43) | KEAP1FFAR1FFAR4PTGER1PTGER4 | |
| SCHEMBL8484227 | 0.66 | KEAP1 (0.50) | KEAP1FFAR1FFAR4PTGER1PTGER4 | |
| SCHEMBL71453 | 0.64 | PTGER4 (0.68) | KEAP1FFAR1FFAR4PTGER1PTGER4 | |
| SCHEMBL6535771 | 0.62 | CDC25A (0.56) | KEAP1FFAR1MEN1LMNAKMT2A | |
| SCHEMBL9264064 | 0.62 | KEAP1 (0.46) | KEAP1FFAR1FFAR4PTGER1PTGER4 | |
| SCHEMBL2426303 | 0.61 | KEAP1 (0.44) | KEAP1FFAR1FFAR4PTGER1PTGER4 | |
| Phenyl Propionic Acid SCHEMBL29619843 | 0.61 | KEAP1 (1.00) | KEAP1FFAR1FFAR4HDAC3MAPK1 | |
| Phenyl Propionic Acid SCHEMBL3419 | 0.61 | KEAP1 (1.00) | KEAP1FFAR1FFAR4HDAC3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006079077-A2 | USE OF DILTIAZEM OR ANALOGS THEREOF AS MODULATORS OF GHRELIN RECEPTOR | ACADIA PHARMACEUTICALS INC. (US) | 2006-07-27 | — | — | WO | disclosed |