Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9632159 | 0.86 | EGFR (0.36) | — | |
| SCHEMBL5801660 | 0.70 | KEAP1 (0.42) | KEAP1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL71453 | 0.69 | PTGER4 (0.68) | KEAP1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8484227 | 0.67 | KEAP1 (0.50) | KEAP1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL59198 | 0.66 | KEAP1 (0.65) | KEAP1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL31212507 | 0.65 | PTGER4 (0.77) | KEAP1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL1261128 | 0.65 | PTGER4 (0.77) | KEAP1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL6053663 | 0.63 | PTGER4 (0.81) | KEAP1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL6535771 | 0.63 | CDC25A (0.56) | KEAP1FFAR1APEX1MEN1LMNA | |
| SCHEMBL9264064 | 0.63 | KEAP1 (0.46) | KEAP1PTGER1PTGER4PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2045483-A | — | — | None | — | — | JP | disclosed |
| JP-2005247778-A | METHOD FOR PRODUCING DIBENZOTHIEPINPROPIONIC ACID DERIVATIVE | MAEKAWA SHIGEJI | 2005-09-15 | — | — | JP | disclosed |
| JP-H0245483-A | PREPARATION OF OPTICALLY ACTIVE DIBENZOTHIEPINPROPIONIC ACID | NIPPON CHEMIPHAR CO LTD | 1990-02-15 | — | — | JP | disclosed |