Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 8/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | PRKACG | P22612 | 1/20 | 0.36 |
| ▸ | PRKACB | P22694 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5805681 | 0.89 | MAPT (0.46) | MAPTKMT2AMEN1IKBKBRAB9A | |
| SCHEMBL5808461 | 0.86 | MAPT (0.57) | MAPTKMT2AMEN1IKBKBRAB9A | |
| SCHEMBL6111195 | 0.83 | IKBKB (0.56) | MAPTKMT2AMEN1IKBKBRAB9A | |
| SCHEMBL5820468 | 0.81 | MAPT (0.45) | MAPTKMT2AMEN1IKBKBRAB9A | |
| SCHEMBL5809220 | 0.81 | KMT2A (0.44) | MAPTKMT2AMEN1RAB9AHTT | |
| SCHEMBL5808459 | 0.80 | MEN1 (0.46) | MAPTKMT2AMEN1ALDH1A1CHRM4 | |
| SCHEMBL5806520 | 0.79 | MAPT (0.45) | MAPTKMT2AMEN1IKBKBRAB9A | |
| SCHEMBL5809588 | 0.78 | MAPT (0.39) | MAPTKMT2AMEN1IKBKBRAB9A | |
| SCHEMBL5808457 | 0.77 | MAPT (0.43) | MAPTKMT2AMEN1IKBKBRAB9A | |
| SCHEMBL5816926 | 0.77 | MAPT (0.43) | MAPTKMT2AMEN1IKBKBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006100095-A1 | SUBSTITUTED CARBOXAMIDES METHOD FOR PRODUCTION AND USE THEREOF AS TNF-ALPHA RELEASE INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-09-28 | — | — | WO | disclosed |