Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | IKBKB | O14920 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5806520 | 0.86 | MAPT (0.45) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL5808461 | 0.86 | MAPT (0.57) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL5808459 | 0.85 | MEN1 (0.46) | MAPTMEN1KMT2ATP53KDM4E | |
| SCHEMBL5808457 | 0.84 | MAPT (0.43) | MAPTMEN1KMT2ARAB9AIKBKB | |
| SCHEMBL5806526 | 0.84 | MAPT (0.44) | MAPTMEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL6110367 | 0.83 | MAPT (0.54) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2856060 | 0.83 | MAPT (0.42) | MAPTMEN1KMT2ARAB9ATP53 | |
| SCHEMBL5820468 | 0.81 | MAPT (0.45) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL5732817 | 0.78 | FOXM1 (0.49) | MAPTMEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL5806498 | 0.77 | MAPT (0.43) | MAPTMEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006100095-A1 | SUBSTITUTED CARBOXAMIDES METHOD FOR PRODUCTION AND USE THEREOF AS TNF-ALPHA RELEASE INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-09-28 | — | — | WO | claimed |