Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 3/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808461 | 0.88 | MAPT (0.57) | MAPTKMT2AMEN1LIMK1IKBKB | |
| SCHEMBL5806520 | 0.83 | MAPT (0.45) | MAPTKMT2AMEN1LIMK1IKBKB | |
| SCHEMBL6112158 | 0.83 | MAPT (0.55) | MAPTKMT2AMEN1LIMK1IKBKB | |
| SCHEMBL5808459 | 0.82 | MEN1 (0.46) | MAPTKMT2AMEN1KDM4ECHRM4 | |
| SCHEMBL2856060 | 0.82 | MAPT (0.42) | MAPTKMT2AMEN1LIMK1ABCG2 | |
| SCHEMBL5808457 | 0.81 | MAPT (0.43) | MAPTKMT2AMEN1IKBKBABCG2 | |
| SCHEMBL5816926 | 0.81 | MAPT (0.43) | MAPTKMT2AMEN1IKBKBKDM4E | |
| SCHEMBL5806498 | 0.81 | MAPT (0.43) | MAPTKMT2AMEN1LIMK1IKBKB | |
| SCHEMBL5806526 | 0.81 | MAPT (0.44) | MAPTKMT2AMEN1ABCG2TP53 | |
| SCHEMBL5809433 | 0.80 | MEN1 (0.43) | MAPTKMT2AMEN1IKBKBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006100095-A1 | SUBSTITUTED CARBOXAMIDES METHOD FOR PRODUCTION AND USE THEREOF AS TNF-ALPHA RELEASE INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-09-28 | — | — | WO | claimed |