Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808461 | 0.88 | MAPT (0.57) | MAPTMEN1KMT2ATP53NPC1 | |
| SCHEMBL5808459 | 0.87 | MEN1 (0.46) | MAPTMEN1KMT2ATP53CHRM4 | |
| SCHEMBL5808457 | 0.86 | MAPT (0.43) | MAPTMEN1KMT2APIM1TP53 | |
| SCHEMBL5816926 | 0.86 | MAPT (0.43) | MAPTMEN1KMT2ATP53NPC1 | |
| SCHEMBL5809433 | 0.85 | MEN1 (0.43) | MAPTMEN1KMT2ASMN1; SMN2IKBKB | |
| SCHEMBL2856060 | 0.84 | MAPT (0.42) | MAPTMEN1KMT2ATP53RAB9A | |
| SCHEMBL5806526 | 0.84 | MAPT (0.44) | MAPTMEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL5820468 | 0.83 | MAPT (0.45) | MAPTMEN1KMT2APIM1TP53 | |
| SCHEMBL5809588 | 0.83 | MAPT (0.39) | MAPTMEN1KMT2APIM1TP53 | |
| SCHEMBL6109707 | 0.82 | MAPT (0.56) | MAPTMEN1KMT2APIM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006100095-A1 | SUBSTITUTED CARBOXAMIDES METHOD FOR PRODUCTION AND USE THEREOF AS TNF-ALPHA RELEASE INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-09-28 | — | — | WO | claimed |
| WO-2006100095-A1 | SUBSTITUTED CARBOXAMIDES METHOD FOR PRODUCTION AND USE THEREOF AS TNF-ALPHA RELEASE INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-09-28 | — | — | WO | disclosed |