Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PRKCI | P41743 | 10/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.40 |
| ▸ | CDC7 | O00311 | 3/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808461 | 0.89 | MAPT (0.57) | MEN1KMT2AMAPTCHRM4KDM4E | |
| SCHEMBL5806520 | 0.87 | MAPT (0.45) | MEN1KMT2AMAPTCHRM4KDM4E | |
| SCHEMBL5808457 | 0.85 | MAPT (0.43) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL5816926 | 0.85 | MAPT (0.43) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL5809433 | 0.84 | MEN1 (0.43) | MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2856060 | 0.83 | MAPT (0.42) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL5806526 | 0.82 | MAPT (0.44) | MEN1KMT2AMAPTTP53 | |
| SCHEMBL5820468 | 0.82 | MAPT (0.45) | MEN1KMT2AMAPTCHRM4KDM4E | |
| SCHEMBL5806498 | 0.80 | MAPT (0.43) | MEN1KMT2AMAPTCHRM4KDM4E | |
| SCHEMBL5809220 | 0.79 | KMT2A (0.44) | MEN1KMT2AMAPTCHRM4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006100095-A1 | SUBSTITUTED CARBOXAMIDES METHOD FOR PRODUCTION AND USE THEREOF AS TNF-ALPHA RELEASE INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-09-28 | — | — | WO | disclosed |