Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | FPR2 | P25090 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856060 | 0.84 | MAPT (0.42) | MAPTMEN1KMT2AABCG2TP53 | |
| SCHEMBL5816926 | 0.84 | MAPT (0.43) | MAPTMEN1KMT2APPARDPPARA | |
| SCHEMBL5808457 | 0.84 | MAPT (0.43) | MAPTMEN1KMT2AABCG2TP53 | |
| SCHEMBL5806520 | 0.84 | MAPT (0.45) | MAPTMEN1KMT2AABCG2TP53 | |
| SCHEMBL5808461 | 0.83 | MAPT (0.57) | MAPTMEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL5808459 | 0.82 | MEN1 (0.46) | MAPTMEN1KMT2ATP53 | |
| SCHEMBL5820468 | 0.81 | MAPT (0.45) | MAPTMEN1KMT2AABCG2TP53 | |
| SCHEMBL5809433 | 0.81 | MEN1 (0.43) | MAPTMEN1KMT2ASCN9AFPR2 | |
| SCHEMBL5809220 | 0.76 | KMT2A (0.44) | MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5805681 | 0.75 | MAPT (0.46) | MAPTMEN1KMT2AADORA3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006100095-A1 | SUBSTITUTED CARBOXAMIDES METHOD FOR PRODUCTION AND USE THEREOF AS TNF-ALPHA RELEASE INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-09-28 | — | — | WO | disclosed |