Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1322906 | 0.85 | MAPT (0.51) | MAPTKMT2AMEN1PARP10BTK | |
| SCHEMBL5806520 | 0.84 | MAPT (0.45) | MAPTKMT2AMEN1TP53ABCG2 | |
| SCHEMBL5808461 | 0.84 | MAPT (0.57) | MAPTKMT2AMEN1TP53GAA | |
| SCHEMBL5806526 | 0.84 | MAPT (0.44) | MAPTKMT2AMEN1TP53ABCG2 | |
| SCHEMBL5808459 | 0.83 | MEN1 (0.46) | MAPTKMT2AMEN1TP53KDM4E | |
| SCHEMBL5816926 | 0.83 | MAPT (0.43) | MAPTKMT2AMEN1TP53GAA | |
| SCHEMBL5808457 | 0.83 | MAPT (0.43) | MAPTKMT2AMEN1TP53GAA | |
| SCHEMBL5809433 | 0.82 | MEN1 (0.43) | MAPTKMT2AMEN1GAAALDH1A1 | |
| SCHEMBL5820468 | 0.82 | MAPT (0.45) | MAPTKMT2AMEN1TP53MCL1 | |
| SCHEMBL5806498 | 0.76 | MAPT (0.43) | MAPTKMT2AMEN1BTKGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773840-B1 | SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINES AND PYRIDO[3',2':4,5]FURO[3,2-D]-PYRIMIDINES FOR USE AS INHIBITORS OF PDA-4 AND/OR TNF-ALPHA RELEASE | MEDICINES CO LEIPZIG GMBH (DE) | 2010-01-20 | — | — | EP | disclosed |