Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ3 | P48549 | 19/20 | 0.50 |
| ▸ | KCNJ6 | P48051 | 18/20 | 0.50 |
| ▸ | KCNJ5 | P48544 | 16/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16347382 | 0.81 | KDM4E (0.43) | KCNJ3KCNJ6KCNJ5 | |
| SCHEMBL31475474 | 0.81 | RXRA (0.49) | KCNJ3KCNJ6KCNJ5 | |
| SCHEMBL25400204 | 0.75 | KCNJ3 (0.45) | KCNJ3KCNJ6KCNJ5 | |
| SCHEMBL31637861 | 0.74 | HCAR3 (0.36) | KCNJ3KCNJ6KCNJ5 | |
| SCHEMBL5804886 | 0.73 | EGFR (0.48) | KCNJ3KCNJ6KCNJ5 | |
| SCHEMBL21604007 | 0.73 | DRD2 (0.34) | KCNJ3KCNJ6KCNJ5 | |
| SCHEMBL23240277 | 0.73 | DRD2 (0.38) | KCNJ3KCNJ6KCNJ5 | |
| SCHEMBL6525498 | 0.73 | KDM4E (0.46) | KCNJ3KCNJ6KCNJ5 | |
| SCHEMBL3364096 | 0.72 | ALDH1A1 (0.49) | KCNJ3KCNJ6KCNJ5 | |
| SCHEMBL31462462 | 0.72 | ALDH1A1 (0.49) | KCNJ3KCNJ6KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |