Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932269 | 0.85 | HSD11B1 (0.59) | KMT2AMEN1HSD11B1ALDH1A1LMNA | |
| SCHEMBL3926842 | 0.84 | HSD11B1 (0.62) | KMT2AMEN1HSD11B1 | |
| SCHEMBL5797968 | 0.82 | KMT2A (0.68) | KMT2AMEN1HSD11B1ALDH1A1CYP2C9 | |
| SCHEMBL5798138 | 0.81 | ALDH1A1 (0.53) | KMT2AMEN1HSD11B1ALDH1A1CYP2C9 | |
| SCHEMBL27815263 | 0.81 | HSD11B1 (0.62) | KMT2AMEN1HSD11B1ALDH1A1LMNA | |
| SCHEMBL3927464 | 0.80 | HSD11B1 (0.54) | KMT2AMEN1HSD11B1ALDH1A1POLB | |
| SCHEMBL5794528 | 0.79 | PKM (0.53) | KMT2AMEN1HSD11B1ALDH1A1CYP2C9 | |
| SCHEMBL5797726 | 0.77 | HSD11B1 (0.55) | HSD11B1ALDH1A1CYP2C9CYP2C19LMNA | |
| SCHEMBL3928523 | 0.76 | HSD11B1 (0.61) | HSD11B1ALDH1A1LMNA | |
| SCHEMBL27650147 | 0.76 | KMT2A (1.00) | KMT2AMEN1ALDH1A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050908-A1 | INHIBITORS OF 11ΒΕΤΑ-HYDROXY STEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) | EVOTEC AG (DE) | 2006-05-18 | — | — | WO | disclosed |