Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.40 |
| ▸ | THRB | P10828 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809194 | 0.90 | THRA (0.41) | THRATHRBKMT2APLA2G2A | |
| SCHEMBL6598958 | 0.85 | ALDH1A1 (0.37) | KMT2AS1PR1NPC1ALDH1A1HPGD | |
| SCHEMBL8624729 | 0.83 | THRA (0.46) | THRATHRBPLA2G2A | |
| SCHEMBL6598709 | 0.82 | THRA (0.44) | THRATHRBKMT2APLA2G2A | |
| SCHEMBL5813886 | 0.82 | THRA (0.38) | THRATHRBKMT2APTPN1PLA2G2A | |
| SCHEMBL5813890 | 0.82 | PPARG (0.38) | THRATHRBPTPN1PLA2G2A | |
| SCHEMBL6603070 | 0.80 | ALDH1A1 (0.37) | KMT2APLA2G2ANPC1ALDH1A1HPGD | |
| SCHEMBL6601718 | 0.80 | PLA2G2A (0.38) | THRATHRBKMT2APLA2G2AALDH1A1 | |
| SCHEMBL5812355 | 0.79 | PLA2G2A (0.39) | THRATHRBKMT2APLA2G2AALDH1A1 | |
| SCHEMBL6601187 | 0.79 | PLA2G2A (0.49) | KMT2APLA2G2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006046683-A1 | THIAZOLYLBENZOFURAN DERIVATIVES AS LEUKOTRIENE AND PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | ASTELLAS PHARMA INC. (JP) | 2006-05-04 | — | — | WO | disclosed |