Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599231 | 0.90 | TSHR (0.42) | TSHRKMT2AMAPTMEN1LMNA | |
| SCHEMBL5599578 | 0.81 | HSD11B1 (0.40) | KCNH2NPSR1MAPTALDH1A1MITF | |
| SCHEMBL5788788 | 0.73 | ALDH1A1 (0.38) | TSHRKMT2AKCNH2MAPTMEN1 | |
| SCHEMBL5787489 | 0.73 | HSD11B1 (0.43) | KMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL5579047 | 0.72 | KMT2A (0.44) | KMT2AKCNH2MEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5598982 | 0.71 | KMT2A (0.43) | TSHRKMT2AKCNH2MAPTMEN1 | |
| SCHEMBL5784831 | 0.71 | KMT2A (0.42) | TSHRKMT2AKCNH2MAPTMEN1 | |
| SCHEMBL5782925 | 0.70 | LMNA (0.39) | KMT2AMAPTMEN1SMN1; SMN2LMNA | |
| SCHEMBL5783676 | 0.70 | ALDH1A1 (0.46) | TSHRKCNH2MAPTSMN1; SMN2LMNA | |
| SCHEMBL5780895 | 0.69 | PSEN1 (0.40) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |