Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820191 | 0.90 | TDP2 (0.40) | TSHRKMT2AMEN1LMNAHTT | |
| SCHEMBL5788788 | 0.83 | ALDH1A1 (0.38) | TSHRKMT2AMEN1LMNAHTT | |
| SCHEMBL5783676 | 0.76 | ALDH1A1 (0.46) | TSHRLMNAHTTMCHR1KDM4E | |
| SCHEMBL5782925 | 0.72 | LMNA (0.39) | KMT2AMEN1LMNAHTTKDM4E | |
| SCHEMBL5599203 | 0.72 | GNRHR (0.39) | NPC1ALDH1A1 | |
| SCHEMBL5780895 | 0.72 | PSEN1 (0.40) | — | |
| SCHEMBL4761766 | 0.70 | PAX8 (0.37) | TSHRLMNAALDH1A1MAPT | |
| SCHEMBL5578809 | 0.69 | KMT2A (0.55) | TSHRKMT2AMEN1KDM4EPOLB | |
| SCHEMBL5599578 | 0.69 | HSD11B1 (0.40) | HTTPOLBALDH1A1MAPT | |
| SCHEMBL5784445 | 0.69 | KDM4E (0.40) | LMNAHTTTP53KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |