Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.52 |
| ▸ | IL1RN | P18510 | 1/20 | 0.52 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.51 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | UQCRB | P14927 | 1/20 | 0.45 |
| ▸ | G6PD | P11413 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10224268 | 0.84 | ALDH1A1 (0.57) | KEAP1IL1RNERAP1ALDH1A1MEN1 | |
| SCHEMBL5161205 | 0.78 | TSHR (0.55) | KEAP1FFAR4CYTH2ALDH1A1MEN1 | |
| SCHEMBL11676191 | 0.75 | CYTH2 (0.65) | KEAP1IL1RNERAP1FFAR4CYTH2 | |
| SCHEMBL2616417 | 0.75 | METAP2 (0.62) | KEAP1FFAR4ALDH1A1GAALMNA | |
| SCHEMBL5822638 | 0.75 | FFAR4 (0.72) | KEAP1IL1RNERAP1FFAR4CYTH2 | |
| SCHEMBL13615049 | 0.74 | CYTH2 (0.59) | KEAP1IL1RNERAP1FFAR4CYTH2 | |
| SCHEMBL2616416 | 0.74 | METAP2 (0.57) | KEAP1FFAR4ALDH1A1LMNA | |
| SCHEMBL5796892 | 0.73 | PKM (0.57) | KEAP1IL1RNERAP1FFAR4CYTH2 | |
| SCHEMBL6817587 | 0.73 | KEAP1 (0.56) | KEAP1IL1RNERAP1FFAR4CYTH2 | |
| SCHEMBL13615341 | 0.73 | ALDH1A1 (0.71) | KEAP1IL1RNERAP1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651595-A2 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2006-05-03 | — | — | EP | claimed |
| WO-2005007621-A2 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | claimed |