Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10875815 | 0.88 | GAA (0.46) | ALDH1A1HPGDPOLBJAK2JAK1 | |
| SCHEMBL7754721 | 0.82 | ALDH1A1 (0.50) | ALDH1A1FEN1HPGDNPC1GLA | |
| SCHEMBL3048180 | 0.78 | CES2 (0.52) | ALDH1A1FEN1HPGDNPC1POLB | |
| SCHEMBL5825610 | 0.76 | CES2 (0.50) | ALDH1A1HPGDNPC1JAK2JAK1 | |
| SCHEMBL23518346 | 0.72 | ALDH1A1 (0.54) | ALDH1A1FEN1HPGDNPC1GLA | |
| SCHEMBL3561938 | 0.72 | KMT2A (0.57) | ALDH1A1CYP3A4MEN1KMT2AAKR1B1 | |
| SCHEMBL3054202 | 0.72 | PARP1 (0.52) | ALDH1A1FEN1HPGDNPC1POLB | |
| SCHEMBL11399312 | 0.72 | FEN1 (0.47) | ALDH1A1FEN1HPGDNPC1GLA | |
| SCHEMBL484004 | 0.71 | L3MBTL1 (0.41) | MEN1KMT2ATDP1CES2CES1 | |
| 1,2-Dichlorobenzene SCHEMBL27532123 | 0.71 | LMNA (0.39) | ALDH1A1HPGDPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106632308-B | Synthesis and application of tertiary amine-benzoyl thiourea bifunctional chiral organic micromolecular catalyst | 山西医科大学 | 2022-02-18 | — | — | CN | disclosed |
| US-7135466-B2 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-14 | — | — | US | disclosed |
| US-20060211717-A1 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-09-21 | — | — | US | disclosed |
| US-20040132727-A1 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN HOLDINGS KABUSHIKI KAISHA (JP) | 2004-07-08 | — | — | US | disclosed |
| EP-1243582-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2002-09-25 | — | — | EP | disclosed |
| EP-0357097-A1 | Benzoylthiourea compounds | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1990-03-07 | — | — | EP | disclosed |
| CN-86101870-A | The preparation and the application thereof of novel benzoyl area kind | — | 1987-01-21 | — | — | CN | disclosed |
| EP-0008435-B1 | SUBSTITUTED N-PHENYL-N'-BENZOYL-THIOUREAS, THEIR PREPARATION AND THEIR USE AS PESTICIDES | BAYER AG (DE) | 1982-05-12 | — | — | EP | disclosed |
| US-4276310-A | ARTHROPODICIDES, FUNGICIDES, BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1981-06-30 | — | — | US | disclosed |
| EP-0008435-A2 | Substituted N-phenyl-N'-benzoyl-thioureas, their preparation and their use as pesticides | BAYER AG (DE) | 1980-03-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211717-A1 | Quinoline and quinazoline derivatives and drugs containing the same | PDGFRA, PDGFRB, PDGFA | ALDH1A1 2003/4885FEN1 3903/4885HPGD 2351/4885 |
| US-20040132727-A1 | Quinoline and quinazoline derivatives and drugs containing the same | PDGFRA, PDGFRB, PDGFA | ALDH1A1 2059/4885FEN1 4098/4885HPGD 2156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.