Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | WRN | Q14191 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7098396 | 0.91 | MGLL (0.50) | MGLLALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL14984834 | 0.87 | PTGS1 (0.49) | MGLLALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL2111408 | 0.87 | PTGS1 (0.58) | MGLLALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL14014722 | 0.84 | MGLL (0.39) | MGLLALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL12021170 | 0.84 | MGLL (0.44) | MGLLALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL5160607 | 0.84 | ALDH1A1 (0.51) | MGLLALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL3874763 | 0.83 | ALDH1A1 (0.63) | MGLLALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL14014719 | 0.83 | MGLL (0.43) | MGLLALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL20637068 | 0.81 | GSK3A (0.65) | MGLLALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL5166306 | 0.81 | MAPK1 (0.58) | MGLLALDH1A1HPGDCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774181-B2 | N-maleimidyl polymer derivatives | NEKTAR THERAPEUTICS (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190330422-A1 | N-MALEIMIDYL POLYMER DERIVATIVES | NEKTAR THERAPEUTICS | 2019-10-31 | — | — | US | disclosed |
| US-10385165-B2 | N-maleimidyl polymer derivatives | NEKTAR THERAPEUTICS (US) | 2019-08-20 | — | — | US | disclosed |
| US-20180051135-A1 | N-MALEIMIDYL POLYMER DERIVATIVES | NEKTAR THERAPEUTICS | 2018-02-22 | — | — | US | disclosed |
| US-9828465-B2 | N-maleimidyl polymer derivatives | NEKTAR THERAPEUTICS (US) | 2017-11-28 | — | — | US | disclosed |
| US-20170088668-A1 | N-MALEIMIDYL POLYMER DERIVATIVES | NEKTAR THERAPEUTICS | 2017-03-30 | — | — | US | disclosed |
| US-9493609-B2 | N-maleimidyl polymer derivatives | NEKTAR THERAPEUTICS (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160083514-A1 | N-MALEIMIDYL POLYMER DERIVATIVES | NEKTAR THERAPEUTICS | 2016-03-24 | — | — | US | disclosed |
| US-9169350-B2 | N-maleimidyl polymer derivatives | NEKTAR THERAPEUTICS (US) | 2015-10-27 | — | — | US | disclosed |
| US-20150166725-A1 | N-Maleimidyl Polymer Derivatives | NEKTAR THERAPEUTICS (US) | 2015-06-18 | — | — | US | disclosed |
| US-8992902-B2 | N-maleimidyl polymer derivatives | NEKTAR THERAPEUTICS (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140256957-A1 | N-Maleimidyl Polymer Derivatives | NEKTAR THERAPEUTICS (US) | 2014-09-11 | — | — | US | disclosed |
| US-8454946-B2 | N-maleimidyl polymer derivatives | NEKTAR THERAPEUTICS (US) | 2013-06-04 | — | — | US | disclosed |
| US-20060013797-A1 | N-maleimidyl polymer derivatives | NEKTAR THERAPEUTICS | 2006-01-19 | — | — | US | disclosed |
| US-6602498-B2 | Water soluble polymer backbone such as polyethylene glycol, endcapped with a N-maleimidyl moiety without using a linker; conjugated peptides, proteins, nucleotides and drugs | SHEARWATER CORPORATION | 2003-08-05 | — | — | US | disclosed |
| US-20010044526-A1 | Water soluble polymer backbone such as polyethylene glycol, endcapped with a N-maleimidyl moiety without using a linker; conjugated peptides, proteins, nucleotides and drugs | SHEARWATER CORPORATION | 2001-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088668-A1 | N-MALEIMIDYL POLYMER DERIVATIVES | NGLY1, PIN1, NMT2 | MGLL 2444/4885ALDH1A1 4566/4885HPGD 1009/4885 |
| US-10385165-B2 | N-maleimidyl polymer derivatives | NGLY1, PIN1, NMT2 | MGLL 2444/4885ALDH1A1 4566/4885HPGD 1009/4885 |
| US-20190330422-A1 | N-MALEIMIDYL POLYMER DERIVATIVES | NGLY1, PIN1, NMT2 | MGLL 2444/4885ALDH1A1 4566/4885HPGD 1009/4885 |
| US-10774181-B2 | N-maleimidyl polymer derivatives | NGLY1, PIN1, NMT2 | MGLL 2444/4885ALDH1A1 4566/4885HPGD 1009/4885 |
| US-20180051135-A1 | N-MALEIMIDYL POLYMER DERIVATIVES | NGLY1, PIN1, NMT2 | MGLL 2444/4885ALDH1A1 4566/4885HPGD 1009/4885 |
| US-20060013797-A1 | N-maleimidyl polymer derivatives | NGLY1, PIN1, NMT2 | MGLL 2444/4885ALDH1A1 4566/4885HPGD 1009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.