Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.31 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.31 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.31 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828040 | 0.84 | LMNA (0.38) | LMNAKDM4ESMN1; SMN2TP53CYP1A2 | |
| SCHEMBL5827618 | 0.80 | FPR2 (0.37) | KDM4EFPR2POLBTP53CYP1A2 | |
| SCHEMBL5828172 | 0.77 | FPR2 (0.39) | KDM4ESMN1; SMN2FPR2KMT2ATP53 | |
| SCHEMBL5827842 | 0.72 | TP53 (0.35) | SMN1; SMN2KMT2ATP53GNAI3GNAO1 | |
| SCHEMBL5828493 | 0.72 | TP53 (0.35) | SMN1; SMN2KMT2ATP53GNAI3GNAO1 | |
| SCHEMBL8277379 | 0.71 | POLB (0.51) | LMNAKDM4ESMN1; SMN2POLBKMT2A | |
| SCHEMBL5827619 | 0.69 | GNAI3 (0.35) | KDM4EFPR2POLBTP53CYP1A2 | |
| SCHEMBL5828173 | 0.68 | KDM4E (0.39) | KDM4ESMN1; SMN2FPR2KMT2ATP53 | |
| SCHEMBL13621551 | 0.67 | RIPK1 (0.37) | TP53CYP1A2TDP1GNAI3GNAO1 | |
| SCHEMBL23089331 | 0.67 | CHRM3 (0.46) | SMN1; SMN2KMT2AALDH1A1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |