Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828173 | 0.84 | KDM4E (0.39) | FPR2KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL5827618 | 0.81 | FPR2 (0.37) | FPR2KDM4ETP53CYP1A2TDP1 | |
| SCHEMBL5828038 | 0.77 | LMNA (0.37) | FPR2KDM4ESMN1; SMN2KMT2ATP53 | |
| SCHEMBL12197840 | 0.72 | KMT2A (0.64) | KDM4ESMN1; SMN2MEN1KMT2ACHRNB4 | |
| SCHEMBL4064292 | 0.70 | EPHX2 (0.40) | KDM4EALDH1A1KDM4C | |
| SCHEMBL25099131 | 0.70 | TSHR (0.36) | FPR2KDM4ETP53ALDH1A1KDM4C | |
| SCHEMBL24369842 | 0.70 | TSHR (0.36) | FPR2KDM4ETP53ALDH1A1KDM4C | |
| SCHEMBL4921739 | 0.69 | NCF1 (0.37) | TP53 | |
| SCHEMBL12448078 | 0.69 | EPHX1 (0.49) | FPR2KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL23866564 | 0.68 | KDM4E (0.55) | KDM4ESMN1; SMN2MEN1KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |