Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | ELANE | P08246 | 1/20 | 0.52 |
| ▸ | CTSG | P08311 | 1/20 | 0.52 |
| ▸ | CMA1 | P23946 | 1/20 | 0.52 |
| ▸ | CTRC | Q99895 | 1/20 | 0.52 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.49 |
| ▸ | EP300 | Q09472 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6096881 | 1.00 | ALDH1A1 (0.67) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL8575466 | 0.84 | MT-CO2 (0.54) | ALDH1A1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL1795199 | 0.84 | FUCA1 (0.50) | ALDH1A1ACHEFUCA1RORCS1PR1 | |
| SCHEMBL1023519 | 0.83 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL13783795 | 0.83 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL12372537 | 0.83 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1TSHRSMN1; SMN2 | |
| SCHEMBL9042636 | 0.83 | SMN1; SMN2 (0.52) | ALDH1A1KMT2AMEN1SMN1; SMN2ACHE | |
| SCHEMBL1749014 | 0.83 | SMN1; SMN2 (0.52) | ALDH1A1KMT2AMEN1SMN1; SMN2ACHE | |
| SCHEMBL24535980 | 0.82 | FUCA1 (0.51) | ALDH1A1TSHRSMN1; SMN2FUCA1RORC | |
| SCHEMBL11031885 | 0.82 | FUCA1 (0.51) | ALDH1A1FUCA1RORCS1PR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020100011-A1 | IMPROVED SYNTHETIC METHODS OF MAKING FUSED HETEROCYCLIC COMPOUNDS AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-05-22 | — | — | WO | disclosed |
| US-9580434-B2 | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes | ATTENUA, INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160039833-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | CATALYST BIOSCIENCES, INC. | 2016-02-11 | — | — | US | disclosed |
| US-20150080576-A1 | SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | TARGACEPT INC (US) | 2015-03-19 | — | — | US | disclosed |
| US-8921410-B2 | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes | TARGACEPT, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |
| US-8859609-B2 | Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes | TARGACEPT, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20130005789-A1 | Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes | TARGACEPT, INC. (US) | 2013-01-03 | — | — | US | disclosed |
| US-20120289572-A1 | Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes | TARGACEPT, INC. (US) | 2012-11-15 | — | — | US | disclosed |
| WO-2005095399-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2005-10-13 | — | — | WO | disclosed |
| WO-2005084667-A1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX, INC. (US) | 2005-09-15 | — | — | WO | disclosed |
| EP-1360187-B1 | 3,7-DIAZABICYCLO(3.3.0)OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| US-20040053986-A1 | 3,7-Diazabicyclo[3.3.0]octanes and their use in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2004-03-18 | — | — | US | disclosed |
| EP-1360187-A1 | 3,7-DIAZABICYCLO(3.3.0)OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002060902-A1 | 3,7-DIAZABICYCLO[3.3.0]OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-08-08 | — | — | WO | disclosed |
| US-6107321-A | Diazabicyclooctane derivatives having selective 5-HT1Dalpha agonist activity | MERCK SHARP & DOHME LTD. (GB) | 2000-08-22 | — | — | US | disclosed |
| WO-1997011945-A1 | DIAZABICYCLOOCTANE DERIVATIVES HAVING SELECTIVE 5-HT1DALPHA ANTAGONIST ACTIVITY | MERCK SHARP & DOHME LIMITED (GB) | 1997-04-03 | — | — | WO | disclosed |
| US-5599816-A | BACTERICIDE | ABBOTT LABORATORIES (US) | 1997-02-04 | — | — | US | disclosed |
| WO-1996039407-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289572-A1 | Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes | CHRNA2, CHRNE, CHRNA7 | ALDH1A1 2128/4885KMT2A 1653/4885MEN1 4492/4885 |
| US-20040053986-A1 | 3,7-Diazabicyclo[3.3.0]octanes and their use in the treatment of cardiac arrhythmias | KCNH1, KCNH2, CACNA1E | ALDH1A1 214/4885KMT2A 3620/4885MEN1 2521/4885 |
| US-20130005789-A1 | Nicotinic Acetylcholine Receptor Sub-Type Selective Amides of Diazabicycloalkanes | CHRNA2, CHRNE, CHRNA7 | ALDH1A1 2128/4885KMT2A 1653/4885MEN1 4492/4885 |
| US-20150080576-A1 | SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | CHRNA4, CHRNA2, CHRNE | ALDH1A1 1883/4885KMT2A 1813/4885MEN1 4644/4885 |
| US-20160039833-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | CHRNA2, CHRNE, CHRNA7 | ALDH1A1 2128/4885KMT2A 1653/4885MEN1 4492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.