Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 14/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 13/20 | 0.34 |
| ▸ | MMP2 | P08253 | 10/20 | 0.34 |
| ▸ | MMP13 | P45452 | 9/20 | 0.34 |
| ▸ | MMP9 | P14780 | 5/20 | 0.34 |
| ▸ | MMP14 | P50281 | 4/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717192 | 0.94 | ADAMTS4 (0.35) | ADAMTS4ADAMTS5MMP2MMP13MMP9 | |
| SCHEMBL5717186 | 0.88 | ADAMTS4 (0.33) | ADAMTS4ADAMTS5MMP2MMP13MMP9 | |
| SCHEMBL5717194 | 0.88 | CYP4F2 (0.38) | ADAMTS4ADAMTS5MMP2MMP13MMP9 | |
| SCHEMBL5717234 | 0.87 | CYP4F2 (0.39) | ADAMTS4ADAMTS5MMP2MMP13MMP9 | |
| SCHEMBL5717222 | 0.87 | PKM (0.43) | MMP13MMP9GPR119ALDH1A1 | |
| SCHEMBL5717417 | 0.86 | GPR119 (0.30) | GPR119 | |
| SCHEMBL5717338 | 0.86 | CYP4F2 (0.41) | ADAMTS4ADAMTS5MMP2GPR119ALDH1A1 | |
| SCHEMBL5717138 | 0.86 | MEN1 (0.44) | MMP13MMP9GPR119ALDH1A1 | |
| SCHEMBL5717379 | 0.86 | CYP4F2 (0.34) | ADAMTS4ADAMTS5MMP2MMP13MMP9 | |
| SCHEMBL5841392 | 0.85 | ITGB3 (0.34) | ADAMTS4ADAMTS5MMP2MMP13MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119203-B2 | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors | PHARMACIA CORPORATION (US) | 2006-10-10 | — | — | US | disclosed |
| US-20050245647-A1 | Flame-retardant polyester fiber and artificial hair comprising the same | KANEKA CORPORATION (JP) | 2005-11-03 | — | — | US | disclosed |
| US-20050209278-A1 | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors | PHARMACIA CORPORATION | 2005-09-22 | — | — | US | disclosed |
| WO-2005042521-A2 | PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2005-05-12 | — | — | WO | disclosed |
| EP-1501827-A2 | PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACID AND THEIR USE AS PROTEASE INHIBITORS | Pharmacia Corporation (US) | 2005-02-02 | — | — | EP | disclosed |
| US-20050009838-A1 | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors | PHARMACIA CORPORATION | 2005-01-13 | — | — | US | disclosed |
| WO-2003091247-A2 | PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209278-A1 | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors | MMP1, PREP, MMP3 | ADAMTS4 36/4885ADAMTS5 23/4885MMP2 4/4885 |
| US-20050009838-A1 | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors | MMP1, PREP, MMP3 | ADAMTS4 36/4885ADAMTS5 23/4885MMP2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.