Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 9/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847498 | 0.87 | FKBP1A (0.43) | FKBP1ARIPK1 | |
| SCHEMBL15494262 | 0.82 | ALDH1A1 (0.52) | FKBP1ARIPK1 | |
| SCHEMBL1685056 | 0.82 | ALDH1A1 (0.52) | FKBP1ARIPK1 | |
| SCHEMBL5846577 | 0.80 | GRM5 (0.64) | GRM5 | |
| SCHEMBL17069015 | 0.79 | HCRTR1 (0.46) | HCRTR1HCRTR2GRM5 | |
| SCHEMBL13805609 | 0.78 | ALDH1A1 (0.54) | HCRTR1HCRTR2 | |
| SCHEMBL14407920 | 0.77 | FKBP1A (0.46) | FKBP1ARIPK1 | |
| SCHEMBL7995090 | 0.76 | FKBP1A (0.57) | FKBP1A | |
| SCHEMBL7995095 | 0.76 | FKBP1A (0.57) | FKBP1A | |
| SCHEMBL14407912 | 0.76 | RIPK1 (0.44) | FKBP1ARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135370-B1 | CARBOXYLIC ACIDS AND CARBOXYLIC ACID ISOSTERES OF N-HETEROCYCLIC COMPOUNDS | GUILFORD PHARM INC (US) | 2003-10-15 | — | — | EP | claimed |
| US-20030186961-A1 | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds | GUILFORD PHARMACEUTICALS | 2003-10-02 | — | — | US | claimed |
| US-7153883-B2 | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds | GPI NIL HOLDINGS INC. (US) | 2006-12-26 | — | — | US | disclosed |
| EP-1135370-B1 | CARBOXYLIC ACIDS AND CARBOXYLIC ACID ISOSTERES OF N-HETEROCYCLIC COMPOUNDS | GUILFORD PHARM INC (US) | 2003-10-15 | — | — | EP | disclosed |
| US-20030186961-A1 | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds | GUILFORD PHARMACEUTICALS | 2003-10-02 | — | — | US | disclosed |
| US-6331537-B1 | TREATING NEUROLOGICAL DISORDERS IN ANIMALS | GPI NIL HOLDINGS, INC. | 2001-12-18 | — | — | US | disclosed |
| EP-1135370-A2 | CARBOXYLIC ACIDS AND CARBOXYLIC ACID ISOSTERES OF N-HETEROCYCLIC COMPOUNDS | GPI NIL Holdings, Inc. (US) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000032588-A2 | CARBOXYLIC ACIDS AND CARBOXYLIC ACID ISOSTERES OF N-HETEROCYCLIC COMPOUNDS | GPI NIL HOLDINGS, INC. (US) | 2000-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186961-A1 | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds | BDNF, NGF, HCAR2 | FKBP1A 887/4885HCRTR1 67/4885HCRTR2 137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.