Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | NPY2R | P49146 | 1/20 | 0.31 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | CPT2 | P23786 | 1/20 | 0.30 |
| ▸ | CPT1A | P50416 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847800 | 0.91 | HTR2A (0.44) | HTR2AHTR2CHTR2BRBP4EPHX2 | |
| SCHEMBL5847475 | 0.90 | S1PR1 (0.37) | HTR2AHTR2CHTR2BEPHX2 | |
| SCHEMBL5847107 | 0.85 | SCD5 (0.37) | HTR2AHTR2CHTR2BRBP4MCHR1 | |
| SCHEMBL5410829 | 0.84 | HTR2A (0.51) | HTR2AHTR2CHTR2BRBP4MCHR1 | |
| SCHEMBL5847619 | 0.81 | CPS1 (0.37) | HTR2AHTR2CHTR2B | |
| SCHEMBL5847121 | 0.80 | CCR3 (0.35) | HTR2AHTR2CHTR2BMCHR1ALDH1A1 | |
| SCHEMBL5846973 | 0.80 | CCR3 (0.34) | HTR2AHTR2CHTR2BMCHR1 | |
| SCHEMBL5847193 | 0.79 | CCR3 (0.35) | HTR2AHTR2CHTR2BKMT2A | |
| SCHEMBL5847324 | 0.79 | CCR3 (0.34) | HTR2AHTR2CHTR2BMAPTALDH1A1 | |
| SCHEMBL5847854 | 0.78 | HCRTR1 (0.36) | HTR2AHTR2CEPHX2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | claimed |
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |