Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847800 | 0.92 | HTR2A (0.44) | HTR2AHTR2CHTR2BEPHX2 | |
| SCHEMBL5847306 | 0.90 | HTR2A (0.36) | HTR2AHTR2CHTR2BEPHX2 | |
| SCHEMBL5847107 | 0.86 | SCD5 (0.37) | HTR2AHTR2CHTR2BEPHX2DPP4 | |
| SCHEMBL5416030 | 0.84 | HTR2A (0.52) | S1PR1S1PR3HTR2AHTR2CHTR2B | |
| SCHEMBL5846973 | 0.82 | CCR3 (0.34) | HTR2AHTR2CHTR2BDPP4 | |
| SCHEMBL5847619 | 0.82 | CPS1 (0.37) | HTR2AHTR2CHTR2B | |
| SCHEMBL5847121 | 0.81 | CCR3 (0.35) | HTR2AHTR2CHTR2B | |
| SCHEMBL5847193 | 0.80 | CCR3 (0.35) | HTR2AHTR2CHTR2BFFAR4 | |
| SCHEMBL5847324 | 0.79 | CCR3 (0.34) | HTR2AHTR2CHTR2B | |
| SCHEMBL5410701 | 0.79 | HTR2A (0.59) | S1PR1S1PR3HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | claimed |
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |