Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3952116 | 0.97 | ALDH1A1 (0.49) | ALDH1A1KMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL2469317 | 0.86 | KMT2A (0.50) | ALDH1A1KMT2ASMN1; SMN2MEN1GAA | |
| Potassium Ion SCHEMBL28796297 | 0.85 | ALDH1A1 (0.59) | ALDH1A1KMT2ASMN1; SMN2MEN1HTT | |
| Potassium Ion SCHEMBL250324 | 0.85 | POLB (0.44) | ALDH1A1KMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL5075923 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KMT2ASMN1; SMN2MEN1HTT | |
| SCHEMBL29396358 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KMT2ASMN1; SMN2MEN1HTT | |
| SCHEMBL10923586 | 0.82 | HSD17B10 (0.63) | ALDH1A1KMT2ASMN1; SMN2MEN1GAA | |
| SCHEMBL27803974 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KMT2ASMN1; SMN2MEN1HTT | |
| SCHEMBL2483870 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KMT2ASMN1; SMN2MEN1HTT | |
| SCHEMBL29558643 | 0.82 | POLB (0.44) | ALDH1A1KMT2ASMN1; SMN2MEN1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1832613-B9 | GRAFT COPOLYMER, METHOD FOR PRODUCING SAME AND RESIN COMPOSITION CONTAINING SUCH GRAFT COPOLYMER | KANEKA CORP (JP) | 2012-08-29 | — | — | EP | disclosed |
| EP-1832613-B1 | GRAFT COPOLYMER, METHOD FOR PRODUCING SAME AND RESIN COMPOSITION CONTAINING SUCH GRAFT COPOLYMER | KANEKA CORP (JP) | 2012-02-15 | — | — | EP | disclosed |
| US-20080242797-A1 | Organopolysiloxane-Containing Graft Copolymer Composition | KANEKA CORPORATION (JP) | 2008-10-02 | — | — | US | disclosed |
| US-20080085975-A1 | Graft Copolymer, Method For Producing The Same And Resin Composition Containing The Graft Copolymer | KANEKA CORPORATION (JP) | 2008-04-10 | — | — | US | disclosed |
| EP-1832613-A1 | GRAFT COPOLYMER, METHOD FOR PRODUCING SAME AND RESIN COMPOSITION CONTAINING SUCH GRAFT COPOLYMER | Kaneka Corporation (JP) | 2007-09-12 | — | — | EP | disclosed |
| EP-1731568-A1 | ORGANOPOLYSILOXANE-CONTAINING GRAFT COPOLYMER COMPOSITION | Kaneka Corporation (JP) | 2006-12-13 | — | — | EP | disclosed |