Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 3/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.35 |
| ▸ | ITGA2 | P17301 | 4/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | RXRB | P28702 | 2/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4530284 | 0.89 | GLS (0.41) | GLSJAK2JAK1TYK2JAK3 | |
| Terephthalic Acid SCHEMBL367597 | 0.84 | EGFR (0.49) | RARARARBRARGEGFRKMO | |
| Terephthalic Acid SCHEMBL17005577 | 0.81 | EGFR (0.46) | RARARARBRARGEGFRKMO | |
| SCHEMBL4534502 | 0.81 | GLS (0.42) | GLSITGB1ITGA2JAK2JAK1 | |
| Terephthalic Acid SCHEMBL27428746 | 0.79 | EGFR (0.44) | RARARARBRARGEGFRKMO | |
| Terephthalic Acid SCHEMBL367109 | 0.78 | KMO (0.50) | RARARARBRARGEGFRKMO | |
| SCHEMBL3294238 | 0.74 | — | — | |
| Terephthalic Acid SCHEMBL3979457 | 0.73 | TSHR (0.50) | EGFRRXRARXRB | |
| SCHEMBL5319785 | 0.71 | BCL2L1 (0.50) | EGFRTRIM24TRIM33RXRARXRB | |
| SCHEMBL9272984 | 0.71 | RARB (0.50) | RARARARBRARGEGFRTRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6981454-B2 | Center post and system for a rack | CAMBRO MANUFACTURING CO. (US) | 2006-01-03 | — | — | US | disclosed |
| US-20040074423-A1 | Center post and system for a rack | CAMBRO MANUFACTURING COMPANY | 2004-04-22 | — | — | US | disclosed |
| US-20020160133-A1 | Food pan cover with an elastomeric seal | CAMBRO MANUFACTURING COMPANY | 2002-10-31 | — | — | US | disclosed |