Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 18/20 | 0.52 |
| ▸ | THRA | P10827 | 16/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5858232 | 0.83 | THRB (0.53) | THRBTHRAPPARG | |
| SCHEMBL5858364 | 0.83 | THRB (0.52) | THRBTHRAPPARG | |
| SCHEMBL5858762 | 0.82 | THRB (0.55) | THRBTHRAPPARG | |
| SCHEMBL7118031 | 0.82 | HTT (0.47) | HCAR3 | |
| SCHEMBL5861455 | 0.81 | HCAR3 (0.46) | THRBTHRAHCAR3 | |
| SCHEMBL27890925 | 0.78 | THRA (0.51) | THRBTHRA | |
| SCHEMBL2785542 | 0.78 | THRB (0.67) | THRBTHRA | |
| SCHEMBL6522547 | 0.76 | HCAR3 (0.57) | HCAR3 | |
| SCHEMBL7250246 | 0.76 | MEN1 (0.46) | THRBTHRA | |
| SCHEMBL27874611 | 0.76 | ALDH1A1 (0.42) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144909-B2 | Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands | KARO BIO AB (SE) | 2006-12-05 | — | — | US | disclosed |
| US-20040116387-A1 | Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands | KARO BIO AB (SE) | 2004-06-17 | — | — | US | disclosed |