Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.50 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 6/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.47 |
| ▸ | PSMB2 | P49721 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863880 | 0.85 | ESR1 (0.47) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL5864176 | 0.82 | LTA4H (0.58) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL5864210 | 0.82 | PDK1 (0.52) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL2475993 | 0.74 | ESR1 (0.75) | KDM4EESR1ESR2PSMB1PSMB5 | |
| SCHEMBL5863633 | 0.74 | KDM4E (0.56) | KDM4EESR1ESR2PSMB1PSMB5 | |
| SCHEMBL5864177 | 0.74 | MMP1 (0.54) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL5649675 | 0.73 | PSMB1 (0.82) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL699174 | 0.73 | ESR1 (0.76) | KDM4EESR1ESR2PSMB1PSMB5 | |
| SCHEMBL1359959 | 0.73 | ESR1 (0.76) | KDM4EESR1ESR2PSMB1PSMB5 | |
| SCHEMBL2112306 | 0.73 | ESR1 (0.62) | KDM4EESR1ESR2PSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053212-B2 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | GHSR, GPER1, SSTR1 | PDK1 3468/4885PDK2 4004/4885PDK3 4168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.