Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 6/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863556 | 0.82 | PDK1 (0.50) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL5864176 | 0.78 | LTA4H (0.58) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL2112306 | 0.75 | ESR1 (0.62) | KDM4EESR1ESR2HRH3ALDH1A1 | |
| SCHEMBL2475993 | 0.74 | ESR1 (0.75) | KDM4EESR1ESR2HRH3 | |
| SCHEMBL5864177 | 0.74 | MMP1 (0.54) | ESR1ESR2HRH3HTT | |
| SCHEMBL5649675 | 0.73 | PSMB1 (0.82) | ESR1ESR2HRH3 | |
| SCHEMBL1359959 | 0.73 | ESR1 (0.76) | KDM4EESR1ESR2HRH3 | |
| SCHEMBL699174 | 0.73 | ESR1 (0.76) | KDM4EESR1ESR2HRH3 | |
| SCHEMBL5863797 | 0.72 | MMP1 (0.61) | HRH3ALDH1A1 | |
| SCHEMBL5864219 | 0.72 | KMT2A (0.55) | ESR1ESR2HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053212-B2 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | GHSR, GPER1, SSTR1 | PDK1 3468/4885PDK2 4004/4885PDK3 4168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.