Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.42 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5865690 | 0.90 | GPR35 (0.49) | TSHRMAPK1GPR35KMT2AMEN1 | |
| SCHEMBL5865568 | 0.88 | GPR35 (0.51) | TSHRMAPK1ATMCYP3A4L3MBTL1 | |
| SCHEMBL5865633 | 0.85 | TSHR (0.59) | TSHRMAPK1ATMCYP3A4L3MBTL1 | |
| SCHEMBL5865624 | 0.82 | VCAM1 (0.66) | TSHRMAPK1ATMCYP3A4L3MBTL1 | |
| SCHEMBL11549838 | 0.81 | ALDH1A1 (0.52) | TSHRMAPK1GPR35KMT2AMEN1 | |
| SCHEMBL5865653 | 0.79 | ALDH1A1 (0.48) | TSHRMAPK1CYP3A4GPR35KMT2A | |
| SCHEMBL5865402 | 0.78 | GPR35 (0.53) | TSHRMAPK1GPR35KMT2AMEN1 | |
| SCHEMBL29473418 | 0.77 | MAPK1 (0.64) | TSHRMAPK1L3MBTL1KMT2AMEN1 | |
| SCHEMBL1511847 | 0.77 | MAPK1 (0.64) | TSHRMAPK1L3MBTL1KMT2AMEN1 | |
| SCHEMBL5865670 | 0.77 | VCAM1 (0.62) | MAPK1GPR35KMT2AMEN1VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091248-B2 | Treatment of adrenocortical hypersecretion and tumor growth | BRANDT INGVAR | 2006-08-15 | — | — | US | disclosed |
| US-20040242705-A1 | Novel treatment of adrenocortical hypersecretion and tumour growth | BRANDT INGVAR (SE) | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242705-A1 | Novel treatment of adrenocortical hypersecretion and tumour growth | NR3C2, NR5A1, NR3C1 | TSHR 118/4885MAPK1 2454/4885ATM 3255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.