Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199557 | 0.94 | GRIN2B (0.47) | SMN1; SMN2ALDH1A1HPGDGRIN2BKCNA5 | |
| SCHEMBL5991146 | 0.84 | NPC1 (0.44) | SMN1; SMN2ALDH1A1GRIN2BKCNA5MAPT | |
| SCHEMBL2889411 | 0.84 | NPC1 (0.44) | SMN1; SMN2ALDH1A1GRIN2BKCNA5MAPT | |
| SCHEMBL2889409 | 0.84 | NPC1 (0.44) | SMN1; SMN2ALDH1A1GRIN2BKCNA5MAPT | |
| Fumaric Acid SCHEMBL2889022 | 0.81 | KCNA5 (0.44) | ALDH1A1KCNA5ABCB1TAAR1 | |
| Maleic Acid SCHEMBL2889017 | 0.81 | KCNA5 (0.44) | ALDH1A1KCNA5ABCB1TAAR1 | |
| Maleic Acid SCHEMBL2889020 | 0.81 | KCNA5 (0.44) | ALDH1A1KCNA5ABCB1TAAR1 | |
| SCHEMBL13476148 | 0.80 | KCNA5 (0.42) | SMN1; SMN2ALDH1A1HPGDGRIN2BKCNA5 | |
| SCHEMBL13476266 | 0.80 | KCNH2 (0.45) | SMN1; SMN2ALDH1A1KCNA5MAPTPKM | |
| SCHEMBL13476183 | 0.80 | KCNA5 (0.46) | SMN1; SMN2ALDH1A1HPGDGRIN2BKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041700-B2 | Substituted benzopyran derivatives against arrhythmia | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2006-05-09 | — | — | US | disclosed |
| US-20040152763-A1 | Substituted benzopyran derivatives against arrhythmia | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152763-A1 | Substituted benzopyran derivatives against arrhythmia | CBR1, KCNH1, SCN8A | KMT2A 2405/4885MEN1 3836/4885SMN1; SMN2 2521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.