Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 6/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 6/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | GRN | P28799 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.37 |
| ▸ | ACE | P12821 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8256279 | 1.00 | RAB9A (0.42) | RAB9AALDH1A1KCNQ3KCNQ2KCNE1 | |
| SCHEMBL8255230 | 0.85 | KMT2A (0.47) | RAB9AALDH1A1NPC1KDM4EACE2 | |
| SCHEMBL5869919 | 0.85 | KMT2A (0.47) | RAB9AALDH1A1NPC1KDM4EACE2 | |
| SCHEMBL5869771 | 0.84 | FOLH1 (0.48) | RAB9AGRIA2NPC1GRNSORT1 | |
| SCHEMBL5869867 | 0.84 | FOLH1 (0.48) | RAB9AGRIA2NPC1GRNSORT1 | |
| SCHEMBL5869763 | 0.84 | FOLH1 (0.48) | RAB9AGRIA2NPC1GRNSORT1 | |
| SCHEMBL8249899 | 0.82 | ALDH1A1 (0.56) | RAB9AALDH1A1KCNQ3KCNQ2NPC1 | |
| SCHEMBL5869783 | 0.82 | ALDH1A1 (0.56) | RAB9AALDH1A1KCNQ3KCNQ2NPC1 | |
| SCHEMBL7420632 | 0.78 | ALDH1A1 (0.41) | RAB9AALDH1A1KCNQ3KCNQ2KCNE1 | |
| SCHEMBL5869254 | 0.77 | TAS1R3 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | RAB9A 2897/4885ALDH1A1 1305/4885KCNQ3 3798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.