Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL7424226 | 0.82 | SLC7A5 (0.40) | CYP2C19POLBTDP1 | |
| SCHEMBL7402628 | 0.82 | CYP2C19 (0.44) | CYP2C19POLBTDP1PKMALDH1A1 | |
| SCHEMBL5870039 | 0.80 | DRD2 (0.42) | — | |
| SCHEMBL5870171 | 0.78 | KMT2A (0.37) | POLBALDH1A1 | |
| SCHEMBL5869881 | 0.75 | SIGMAR1 (0.46) | CYP2C19ALDH1A1 | |
| SCHEMBL8256609 | 0.71 | LMNA (0.43) | ALDH1A1 | |
| SCHEMBL5869768 | 0.71 | LMNA (0.43) | ALDH1A1 | |
| SCHEMBL7383855 | 0.69 | CYP2C19 (0.44) | CYP2C19POLBTDP1PKMALDH1A1 | |
| SCHEMBL5870149 | 0.69 | RAB9A (0.45) | PKM | |
| SCHEMBL8249703 | 0.69 | RAB9A (0.45) | PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |