Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869876 | 0.78 | CYP2C19 (0.42) | ALDH1A1POLB | |
| SCHEMBL5869881 | 0.75 | SIGMAR1 (0.46) | KMT2AALDH1A1MAPK1ALOX5 | |
| SCHEMBL7374984 | 0.75 | NR4A2 (0.53) | KMT2AALDH1A1MAPK1POLBNR4A2 | |
| SCHEMBL7374986 | 0.75 | NR4A2 (0.53) | KMT2AALDH1A1MAPK1POLBNR4A2 | |
| SCHEMBL5870039 | 0.74 | DRD2 (0.42) | PTGS1PTGS2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL5869768 | 0.69 | LMNA (0.43) | KMT2AALDH1A1MAPK1TSHRNPC1 | |
| SCHEMBL8256609 | 0.69 | LMNA (0.43) | KMT2AALDH1A1MAPK1TSHRNPC1 | |
| SCHEMBL8628859 | 0.67 | RIPK1 (0.48) | KMT2AALDH1A1MAPK1POLBTSHR | |
| SCHEMBL18339358 | 0.66 | USP2 (0.43) | KMT2AALDH1A1MAPK1POLBPTGS1 | |
| SCHEMBL16087980 | 0.66 | TDP1 (0.50) | KMT2AALDH1A1TSHRSLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |