Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 6/20 | 0.46 |
| ▸ | MME | P08473 | 3/20 | 0.45 |
| ▸ | CTSL | P07711 | 10/20 | 0.44 |
| ▸ | CTSV | O60911 | 9/20 | 0.44 |
| ▸ | CTSS | P25774 | 9/20 | 0.44 |
| ▸ | CTSK | P43235 | 7/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | MMEL1 | Q495T6 | 2/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870209 | 1.00 | CTSB (0.46) | CTSBMMECTSLCTSVCTSS | |
| SCHEMBL5870203 | 1.00 | CTSB (0.46) | CTSBMMECTSLCTSVCTSS | |
| SCHEMBL8254871 | 0.85 | MAPK1 (0.55) | CTSBCTSLCTSVCTSSCTSK | |
| SCHEMBL5870478 | 0.85 | MAPK1 (0.55) | CTSBCTSLCTSVCTSSCTSK | |
| SCHEMBL23901512 | 0.80 | PNMT (0.53) | CTSBCTSLCTSVCTSSCTSK | |
| SCHEMBL16287362 | 0.80 | CTSL (0.52) | CTSBCTSLCTSVCTSSCTSK | |
| SCHEMBL31369749 | 0.80 | CTSL (0.52) | CTSBCTSLCTSVCTSSCTSK | |
| SCHEMBL29539732 | 0.80 | CTSL (0.52) | CTSBCTSLCTSVCTSSCTSK | |
| SCHEMBL805207 | 0.80 | CTSL (0.52) | CTSBCTSLCTSVCTSSCTSK | |
| SCHEMBL5869465 | 0.80 | MME (0.66) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | CTSB 438/4885MME 11/4885CTSL 911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.