Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.42 |
| ▸ | DRD2 | P14416 | 8/20 | 0.42 |
| ▸ | HTR1A | P08908 | 7/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 6/20 | 0.39 |
| ▸ | HRH1 | P35367 | 5/20 | 0.39 |
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | DRD1 | P21728 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | HRH2 | P25021 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871394 | 0.88 | ADRA1A (0.42) | HTR2ADRD2HTR1AHRH3ADRA1A | |
| SCHEMBL5871585 | 0.84 | ADRA1A (0.48) | HTR2ADRD2HTR1AHRH3ADRA1A | |
| SCHEMBL5871443 | 0.82 | HTR1A (0.53) | HTR2ADRD2HTR1AHRH3ADRA1A | |
| SCHEMBL5871114 | 0.75 | HTR2A (0.46) | HTR2ADRD2ADRA1AADRA1BADRA1D | |
| SCHEMBL5871132 | 0.66 | SIGMAR1 (0.61) | HTR2ADRD2HTR2CHTR2BSIGMAR1 | |
| SCHEMBL5871090 | 0.62 | SCD (0.45) | HTR2ADRD2HTR1AADRA1AADRA1B | |
| SCHEMBL5871488 | 0.62 | SIGMAR1 (0.64) | HTR2ADRD2HRH3HTR2CHTR2B | |
| SCHEMBL5872075 | 0.62 | HTR2A (0.53) | HTR2ADRD2HTR1AHTR2CHTR6 | |
| SCHEMBL5872403 | 0.62 | MTNR1B (0.56) | DRD2HTR1AADRA1AADRA1BADRA1D | |
| Hydrochloric Acid SCHEMBL5870972 | 0.61 | MTNR1B (0.56) | DRD2HTR1AADRA1AADRA1BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071201-B2 | Serotonin antagonism; muscle relaxant for myotonia; such as 1-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)-7-methoxy-1,2,3,4 -tetrahydroquinoline | EISAI CO., LTD. (JP) | 2006-07-04 | — | — | US | disclosed |
| US-6579881-B2 | Indoles | EISAI CO., LTD. (JP) | 2003-06-17 | — | — | US | disclosed |
| US-6448243-B1 | SEROTONIN ANTAGONIST FOR TREATING, AMELIORATING AND PREVENTING SPASTIC PARALYSIS OR CENTRAL MUSCLE RELAXANTS FOR AMELIORATING MYOTONIA | EISAI CO., LTD. (JP) | 2002-09-10 | — | — | US | disclosed |
| US-20020086999-A1 | Certain quinoline derivatives | EISAI CO., LTD. | 2002-07-04 | — | — | US | disclosed |
| US-20020019531-A1 | Indoles | EISAI CO., LTD. | 2002-02-14 | — | — | US | disclosed |
| EP-0976732-A1 | 1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-02-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019531-A1 | Indoles | INMT, MUSK, MB | HTR2A 209/4885DRD2 51/4885HTR1A 17/4885 |
| US-20020086999-A1 | Certain quinoline derivatives | CHRM1, CHRNA5, CHRNA4 | HTR2A 143/4885DRD2 54/4885HTR1A 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.