⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6688284 | 0.78 | POLB (0.38) | — | |
| SCHEMBL77388 | 0.78 | POLB (0.33) | — | |
| SCHEMBL9697351 | 0.77 | POLB (0.32) | — | |
| SCHEMBL9119329 | 0.74 | PLA2G7 (0.31) | — | |
| SCHEMBL2714868 | 0.72 | KMT2A (0.32) | — | |
| SCHEMBL5872342 | 0.72 | MAPT (0.31) | — | |
| SCHEMBL10369791 | 0.71 | LMNA (0.33) | — | |
| SCHEMBL14979751 | 0.71 | PLA2G7 (0.30) | — | |
| SCHEMBL6163515 | 0.71 | BDKRB2 (0.36) | — | |
| SCHEMBL6167979 | 0.70 | MEN1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109259-B2 | Piperazinone derivatives | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2006-09-19 | — | — | US | disclosed |
| US-20030027902-A1 | Piperazinone derivatives | LAZZARI DARIO (IT) | 2003-02-06 | — | — | US | disclosed |
| EP-0361536-B1 | Process for preparing polysubstituted piperazinones | GOODRICH CO B F (US) | 1995-09-06 | — | — | EP | disclosed |
| EP-0209871-B1 | SUBSTITUTED OXO-PIPERAZINYL-TRIAZINES AND UV LIGHT STABILIZED COMPOSITIONS | The B.F. GOODRICH Company (US) | 1990-09-26 | — | — | EP | disclosed |
| EP-0361536-A1 | Process for preparing polysubstituted piperazinones | THE B.F. GOODRICH COMPANY (US) | 1990-04-04 | — | — | EP | disclosed |
| US-4687850-A | DISTILLATION WITH BASE | THE B.F. GOODRICH COMPANY (US) | 1987-08-18 | — | — | US | disclosed |
| EP-0209871-A1 | Substituted oxo-piperazinyl-triazines and UV light stabilized compositions | The B.F. GOODRICH Company (US) | 1987-01-28 | — | — | EP | disclosed |
| US-4629752-A | PHOTOSTABILIZERS FOR POLYOLEFINS; POLYSUBSTITUTED | THE B. F. GOODRICH COMPANY (US) | 1986-12-16 | — | — | US | disclosed |
| EP-0184154-A1 | Purification of 1-(2-Amino-2-alkylpropyl)-3,3,5,5,-tetraalkylpiperazinones | The B.F. GOODRICH Company (US) | 1986-06-11 | — | — | EP | disclosed |