SCHEMBL5873448

SCHEMBL5873448

OCC1(c2ccc(Cl)cc2)CCCC1

nearest known ligand 0.63

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 11/20 0.63
SLC6A3 Q01959 10/20 0.63
SLC6A2 P23975 6/20 0.58
DRD2 P14416 2/20 0.45
DRD4 P21917 1/20 0.45
DRD3 P35462 1/20 0.45
HDAC4 P56524 1/20 0.44
PRKAB2 O43741 2/20 0.42
PRKAG1 P54619 2/20 0.42
PRKAA2 P54646 2/20 0.42
PRKAA1 Q13131 2/20 0.42
PRKAG3 Q9UGI9 2/20 0.42
PRKAG2 Q9UGJ0 2/20 0.42
PRKAB1 Q9Y478 2/20 0.42
P2RX7 Q99572 1/20 0.42
HSD11B1 P28845 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28438976 0.98 SLC6A4 (0.67) SLC6A4SLC6A3SLC6A2DRD2DRD4
SCHEMBL2129 0.96 SLC6A4 (0.58) SLC6A4SLC6A3SLC6A2DRD2DRD4
SCHEMBL3615305 0.91 SLC6A4 (0.52) SLC6A4SLC6A3SLC6A2DRD2DRD4
SCHEMBL10633566 0.82 SLC6A3 (0.62) SLC6A4SLC6A3SLC6A2HDAC4HSD11B1
SCHEMBL188283 0.82 SLC6A4 (0.60) SLC6A4SLC6A3SLC6A2DRD2DRD4
SCHEMBL11826316 0.81 PDE4A (0.45) SLC6A4SLC6A3SLC6A2DRD2DRD4
SCHEMBL16565548 0.80 P2RX7 (0.52) SLC6A4SLC6A3SLC6A2DRD2DRD4
SCHEMBL21078008 0.80 DRD2 (0.49) SLC6A4SLC6A3SLC6A2DRD2DRD4
SCHEMBL9804270 0.79 SLC6A4 (0.44) SLC6A4SLC6A3SLC6A2DRD2DRD4
SCHEMBL3891504 0.79 SLC6A3 (0.63) SLC6A4SLC6A3SLC6A2HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6989052-B1 Phase change ink printing process XEROX CORPORATION (US) 2006-01-24 US claimed
US-20060004123-A1 PHASE CHANGE INK PRINTING PROCESS XEROX CORPORATION 2006-01-05 US claimed
US-5922117-A Ink compositions containing alcohols XEROX CORPORATION (US) 1999-07-13 US claimed
EP-3426246-B1 THIAZOLIDINONE COMPOUNDS AND USE THEREOF NATIONAL HEALTH RES INST (TW) 2024-05-01 EP disclosed
US-10544113-B2 Thiazolidinone compounds and use thereof NATIONAL HEALTH RESEARCH INSTITUTE (TW) 2020-01-28 US disclosed
US-10544113-B2 Thiazolidinone compounds and use thereof NATIONAL HEALTH RESEARCH INSTITUTE (TW) 2020-01-28 US disclosed
EP-3426246-A1 THIAZOLIDINONE COMPOUNDS AND USE THEREOF National Health Research Institutes (TW) 2019-01-16 EP disclosed
CN-108883099-A THIAZOLIDINONE COMPOUNDS AND USE THEREOF 石全 2018-11-23 CN disclosed
WO-2017155910-A1 THIAZOLIDINONE COMPOUNDS AND USE THEREOF NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2017-09-14 WO disclosed
WO-2017155910-A1 THIAZOLIDINONE COMPOUNDS AND USE THEREOF NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2017-09-14 WO disclosed
US-20170253569-A1 THIAZOLIDINONE COMPOUNDS AND USE THEREOF REGENTS OF THE UNIVERSITY OF MINNESOTA 2017-09-07 US disclosed
US-20140194431-A1 PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE SAVIRA PHARMACEUTICALS GMBH (AT) 2014-07-10 US disclosed
US-6989052-B1 Phase change ink printing process XEROX CORPORATION (US) 2006-01-24 US disclosed
US-20060004123-A1 PHASE CHANGE INK PRINTING PROCESS XEROX CORPORATION 2006-01-05 US disclosed
EP-0976734-B1 Selective inhibitors of viral or bacterial neuraminidase GILEAD SCIENCES INC (US) 2005-09-28 EP disclosed
EP-0759917-B1 NOVEL SELECTIVE INHIBITORS OF VIRAL OR BACTERIAL NEURAMINIDASES GILEAD SCIENCES INC (US) 2000-04-12 EP disclosed
US-5922117-A Ink compositions containing alcohols XEROX CORPORATION (US) 1999-07-13 US disclosed
WO-1998020878-A1 5-[φ-(SUBSTITUTED ARYL)ALKENYLENE AND ALKYNYLENE]-2,4-DIAMINOPYRIMIDINES AS PESTICIDES FMC CORPORATION (US) 1998-05-22 WO disclosed
US-5696259-A 2,4-diamino-5-iodopyrimidines useful as pesticide intermediates FMC CORPORATION (US) 1997-12-09 US disclosed
US-5622954-A INSECTICIDE FMC CORPORATION (US) 1997-04-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10544113-B2 Thiazolidinone compounds and use thereof OPRL1, OPRD1, OPRK1 SLC6A4 354/4885SLC6A3 220/4885SLC6A2 559/4885
US-20140194431-A1 PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE TPMT, XDH, DPYD SLC6A4 359/4885SLC6A3 130/4885SLC6A2 276/4885
US-20170253569-A1 THIAZOLIDINONE COMPOUNDS AND USE THEREOF OPRL1, OPRD1, OPRK1 SLC6A4 354/4885SLC6A3 220/4885SLC6A2 559/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.