Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | KDM5A | P29375 | 4/20 | 0.53 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 6/20 | 0.42 |
| ▸ | PPARD | Q03181 | 6/20 | 0.42 |
| ▸ | PPARA | Q07869 | 6/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TLR2 | O60603 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL5874857 | 1.00 | CA12 (0.54) | CA12CA1CA9KDM5APHF8 | |
| Acetic Acid SCHEMBL692128 | 0.92 | CA12 (0.52) | CA12CA1CA9KDM5APHF8 | |
| Oxalic Acid SCHEMBL5874878 | 0.92 | CA12 (0.52) | CA12CA1CA9KDM5APHF8 | |
| Acetic Acid SCHEMBL27778890 | 0.92 | CA12 (0.52) | CA12CA1CA9KDM5APHF8 | |
| Oxalic Acid SCHEMBL5844731 | 0.92 | CA12 (0.52) | CA12CA1CA9KDM5APHF8 | |
| Hydrogen Peroxide SCHEMBL137833 | 0.91 | KDM5A (0.48) | CA12CA1CA9KDM5APHF8 | |
| Hydrogen Peroxide SCHEMBL137835 | 0.91 | KDM5A (0.48) | CA12CA1CA9KDM5APHF8 | |
| Bicarbonate SCHEMBL1131246 | 0.90 | KDM5A (0.47) | CA12CA1CA9KDM5APHF8 | |
| Bicarbonate SCHEMBL1132307 | 0.90 | KDM5A (0.47) | CA12CA1CA9KDM5APHF8 | |
| Bicarbonate SCHEMBL28356729 | 0.89 | KDM5A (0.56) | KDM5APHF8KDM4CAKR1B1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113501779-A | Method for selectively removing benzyl, allyl and propargyl protecting groups initiated by visible light or near visible light | 云南大学 | 2021-10-15 | — | — | CN | claimed |
| US-12065461-B2 | Method for preparing 3′-O-amino-2′-deoxyribonucleoside-5′-triphosphate | DNA SCRIPT (FR) | 2024-08-20 | — | — | US | disclosed |
| CN-117303615-A | Treatment process of high-mineralization oily sewage | 中国石油天然气股份有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-111448203-B | Efficient process for preparing cangrelor | 欧伦股份公司 | 2023-06-13 | — | — | CN | disclosed |
| CN-116134068-A | Polymerization process | 牛津大学科技创新有限公司 | 2023-05-16 | — | — | CN | disclosed |
| US-20220389048-A1 | PROCESS FOR PREPARING 3'-O-AMINO-RIBONUCLEOTIDE | DNA SCRIPT SAS (FR) | 2022-12-08 | — | — | US | disclosed |
| US-11312742-B2 | Process for preparing 3'-O-amino-ribonucleotide | DNA SCRIPT SAS (FR) | 2022-04-26 | — | — | US | disclosed |
| US-11279724-B2 | Efficient method for the preparation of Cangrelor | OLON S.P.A. (IT) | 2022-03-22 | — | — | US | disclosed |
| EP-3707148-B1 | EFFICIENT METHOD FOR THE PREPARATION OF CANGRELOR | OLON SPA (IT) | 2022-01-05 | — | — | EP | disclosed |
| EP-3924359-A1 | PROCESS FOR PREPARING 3'-O-AMINO-RIBONUCLEOTIDE | DNA Script (FR) | 2021-12-22 | — | — | EP | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| US-6316668-B1 | RECOVERING CARBOXYLIC ACID IN SOLID PHASE; COMPLEXING ALKYLAMINE-CARBOXYLIC ACID; HEATING TO DECOMPOSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2001-11-13 | — | — | US | disclosed |
| US-6143877-A | FORMING A TRIPLEX BY CONTACTING DUPLEX NUCLEIC ACID HAVING A TARGET SEQUENCE OF PURINE BASES WITH A OLIGONUCLEOTIDE HAVING AT LEAST ONE GUANINE BASE REPLACED BY 6-AMINO-1H-PYRAZOLO(3,4-D)PYRIMIDIN-4(5H)-ONE | EPOCH PHARMACEUTICALS, INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6072046-A | SELECTIVELY FORM TRIPLEXES WITH A COMPLEMENTARY TARGET SEQUENCE IN DOUBLE-STRANDED DNA AND EFFICIENTLY CROSSLINK WITH BOTH STRANDS; THERAPEUTICS, DIAGNOSTICS, AND GENETIC PROBES | EPOCH PHARMACEUTICALS, INC. (US) | 2000-06-06 | — | — | US | disclosed |
| WO-2000012523-A1 | DIAZIRIDINYL-ARYL AND BIS-[DI(CHLOROETHYL)AMINO]-ARYL OLIGONUCLEOTIDE CONJUGATES AND REAGENTS FOR MAKING THE SAME | EPOCH PHARMACEUTICALS, INC. (US) | 2000-03-09 | — | — | WO | disclosed |
| WO-1998049180-A1 | TRIPLEX FORMING OLIGONUCLEOTIDES INCLUDING PYRAZOLO(3,4-D)PYRIMIDINE BASES | EPOCH PHARMACEUTICALS, INC. (US) | 1998-11-05 | — | — | WO | disclosed |
| US-5412126-A | Reaction with alkylamine to form salt, separation, decomposition | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0507188-A1 | Substituted 2',3'-dideoxy-5-trifluoromethyluridines, method of their preparation and their use in medicaments | BAYER AG (DE) | 1992-10-07 | — | — | EP | disclosed |
| US-5132456-A | Sorption of carboxylic acid from carboxylic salt solutions at PHS close to or above the pKa of the acid, with regeneration with an aqueous solution of ammonia or low-molecular-weight alkylamine | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1992-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312742-B2 | Process for preparing 3'-O-amino-ribonucleotide | NSUN3, RNMT, NSUN2 | CA12 3602/4885CA1 3875/4885CA9 2425/4885 |
| US-12065461-B2 | Method for preparing 3′-O-amino-2′-deoxyribonucleoside-5′-triphosphate | NUDT1, TYMP, DUT | CA12 3929/4885CA1 3876/4885CA9 3713/4885 |
| US-20220389048-A1 | PROCESS FOR PREPARING 3'-O-AMINO-RIBONUCLEOTIDE | NSUN3, RNMT, NSUN2 | CA12 3602/4885CA1 3875/4885CA9 2425/4885 |
| US-11279724-B2 | Efficient method for the preparation of Cangrelor | NOTUM, CYP4A11, CANX | CA12 3829/4885CA1 4109/4885CA9 1794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.